Turk J Med Sci. 2015;45(1):70-5. doi: 10.3906/sag-1311-52.
BACKGROUND/AIM: To investigate the distribution of viral genotypes, the extrahepatic manifestations, and the relationship between genotypes and extrahepatic manifestations in patients with chronic hepatitis C.
The study included 62 treatment-naive patients with chronic hepatitis C infection. Genotype determination was performed by DNA sequencing analysis. To investigate extrahepatic manifestations, the patients' data, recorded prospectively during the pretreatment period, were analyzed.
Genotype determination was successful in 74.2% of the cases. All patients were infected with hepatitis C virus (HCV) genotype lb. At least 1 extrahepatic manifestation was identified in 37.1% of the patients. The most frequent clinical manifestations were type II diabetes mellitus (8.1%) and arthralgia or arthritis (8.0%). There was no relationship between extrahepatic manifestations and fibrosis or transaminase levels, but female sex and advanced age were risk factors. Because all patients were infected with the same genotype, the relationship between extrahepatic manifestations and genotype could not be examined.
HCV genotype 1b is predominant in patients with chronic hepatitis C in the Eastern Anatolian Region of Turkey. In total, 37.1% of the patients had at least 1 extrahepatic manifestation. Female sex and advanced age were risk factors for having extrahepatic manifestations.
背景/目的：调查慢性丙型肝炎患者病毒基因型的分布、肝外表现以及基因型与肝外表现之间的关系。
本研究纳入了 62 例未经治疗的慢性丙型肝炎感染患者。通过 DNA 测序分析进行基因型测定。为了调查肝外表现，分析了患者在治疗前期间前瞻性记录的数据。
74.2%的病例成功进行了基因型测定。所有患者均感染了丙型肝炎病毒（HCV）基因型 1b。37.1%的患者至少存在 1 种肝外表现。最常见的临床表现为 II 型糖尿病（8.1%）和关节痛或关节炎（8.0%）。肝外表现与纤维化或转氨酶水平之间无相关性，但女性和高龄是危险因素。由于所有患者均感染了相同的基因型，因此无法检查肝外表现与基因型之间的关系。
土耳其东安纳托利亚地区慢性丙型肝炎患者以 HCV 基因型 1b 为主。总的来说，37.1%的患者至少存在 1 种肝外表现。女性和高龄是发生肝外表现的危险因素。
