Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015 Jan;35(1):41-5.
To observe the intervention effect of nourishing Xin and Shen method (NXSM) on the cognitive function of mild cognitive impairment due to subcortical small vessel disease (MCI-SSVD).
All 54 MCI-SSVD patients came from Department of Traditional Chinese Medicine, Affiliated Union Hospital of Fujian Medical University from June 2010 to August 2013. They were randomly assigned to the treatment group (28 cases) and the control group (26 cases). Another 33 volunteers were recruited as a healthy control group. On the basis of targeting risk factors of blood vessels, MCI-SSVD patients were treated respectively with NXSM and donepezil hydrochloride, with the therapeutic course of 12 weeks. Neuropsychological scales [mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA)], and Chinese medical dementia syndrome scales were performed in all subjects, and results were compared among groups or intra-group before and after treatment.
MMSE and MoCA scores of the two treatment groups decreased more, when compared with those of the healthy control group (P < 0.05). In particular, MoCA score was significantly decreased (P < 0.01). MMSE and MoCA scores of the two treatment groups increased more after treatment than before treatment (P < 0.05). But there was no statistical difference in MMSE or MOCA score after treatment between the two groups (P > 0.05). Chinese medical dementia syndrome scales decreased more significantly in the treatment group, when compared with before treatment (P < 0.01). But there was no statistical difference in Chinese medical dementia syndrome scales in the control group between before and after treatment (P > 0.05). Visual spatial and executive function scores or delayed recall scores of the two treatment groups increased more, when compared with the same group before treatment (P < 0.05, P < 0.01).
NXSM could effectively improve cognitive functions of MCI-SSVD.
观察养心安神法对皮质下小血管病所致轻度认知功能障碍（MCI - SSVD）患者认知功能的干预效果。
选取2010年6月至2013年8月福建医科大学附属协和医院中医科收治的54例MCI - SSVD患者，随机分为治疗组（28例）和对照组（26例）。另招募33名志愿者作为健康对照组。在针对血管危险因素的基础上，MCI - SSVD患者分别采用养心安神法和盐酸多奈哌齐进行治疗，疗程为12周。对所有受试者进行神经心理学量表[简易精神状态检查表（MMSE）和蒙特利尔认知评估量表（MoCA）]以及中医痴呆综合征量表评估，并比较各组治疗前后组间及组内结果。
与健康对照组相比，两个治疗组的MMSE和MoCA评分下降更为明显（P < 0.05）。特别是MoCA评分显著下降（P < 0.01）。两个治疗组治疗后的MMSE和MoCA评分较治疗前升高更为明显（P < 0.05）。但两组治疗后MMSE或MoCA评分差异无统计学意义（P > 0.05）。与治疗前相比，治疗组中医痴呆综合征量表下降更为显著（P < 0.01）。但对照组中医痴呆综合征量表治疗前后差异无统计学意义（P > 0.05）。与治疗前同一组相比，两个治疗组的视觉空间与执行功能评分或延迟回忆评分升高更为明显（P < 0.05，P < 0.01）。
养心安神法可有效改善MCI - SSVD患者的认知功能。
