钙加维生素D补充剂对妊娠期糖尿病患者的妊娠结局有影响：随机、双盲、安慰剂对照试验。
Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial.
作者信息
Karamali Maryam, Asemi Zatollah, Ahmadi-Dastjerdi Maedeh, Esmaillzadeh Ahmad
机构信息
1Department of Gynecology and Obstetrics,School of Medicine,Arak University of Medical Sciences,Arak,Islamic Republic of Iran.
2Department of Nutrition,Research Center for Biochemistry and Nutrition in Metabolic Diseases,Kashan University of Medical Sciences,Kashan,Islamic Republic of Iran.
出版信息
Public Health Nutr. 2016 Jan;19(1):156-63. doi: 10.1017/S1368980015000609. Epub 2015 Mar 20.
OBJECTIVE
The present study was designed to assess the effects of Ca+vitamin D supplementation on pregnancy outcomes in women with gestational diabetes mellitus (GDM).
DESIGN
A randomized, double-blind, placebo-controlled trial was conducted among sixty women with GDM. Participants were divided into two groups to receive Ca+vitamin D supplements or placebo. Individuals in the Ca+vitamin D group (n 30) received 1000 mg Ca/d and two pearls containing 1250 µg (50 000 IU) of cholecalciferol (vitamin D(3)) during the intervention (one at study baseline and another at day 21 of the intervention); those in the placebo group (n 30) received two placebos of vitamin D at the mentioned times and placebos of Ca every day for 6 weeks. Pregnancy outcomes were determined.
SETTING
A urban community setting in Arak, Iran.
SUBJECTS
Sixty women with GDM and their newborns, living in Arak, Iran were enrolled.
RESULTS
Women treated with Ca+vitamin D had a significant decrease in caesarean section rate (23·3 % v. 63·3 %, P=0·002) and maternal hospitalization (0 v. 13·3 %, P=0·03) compared with those receiving placebo. In addition, newborns of GDM women randomized to Ca+vitamin D had no case of macrosomia, while the prevalence of macrosomia among those randomized to placebo was 13·3 % (P=0·03). Lower rates of hyperbilirubinaemia (20·0 % v. 56·7 %, P=0·03) and hospitalization (20·0 % v. 56·7 %, P=0·03) were also seen in the supplemented group of newborns than in the placebo group.
CONCLUSIONS
Ca+vitamin D supplementation for 6 weeks among pregnant women with GDM led to decreased caesarean section rate and maternal hospitalization, and decreased macrosomia, hyperbilirubinaemia and hospitalization in newborns.
目的
本研究旨在评估补充钙和维生素D对妊娠期糖尿病（GDM）女性妊娠结局的影响。
设计
对60例GDM女性进行了一项随机、双盲、安慰剂对照试验。参与者被分为两组，分别接受钙加维生素D补充剂或安慰剂。钙加维生素D组（n = 30）在干预期间每天服用1000 mg钙和两颗含1250 μg（50 000 IU）胆钙化醇（维生素D3）的药丸（一颗在研究基线时服用，另一颗在干预第21天服用）；安慰剂组（n = 30）在上述时间服用两颗维生素D安慰剂，每天服用钙安慰剂，持续6周。确定妊娠结局。
地点
伊朗阿拉克的一个城市社区。
研究对象
招募了居住在伊朗阿拉克的60例GDM女性及其新生儿。
结果
与接受安慰剂的女性相比，接受钙加维生素D治疗的女性剖宫产率（23.3%对63.3%，P = 0.002）和产妇住院率（0对13.3%，P = 0.03）显著降低。此外，随机接受钙加维生素D的GDM女性的新生儿无巨大儿病例，而随机接受安慰剂的新生儿巨大儿患病率为13.3%（P = 0.03）。补充组新生儿的高胆红素血症发生率（20.0%对56.7%，P = 0.03）和住院率（20.0%对56.7%，P = 0.03）也低于安慰剂组。
结论
GDM孕妇补充钙和维生素D 6周可降低剖宫产率和产妇住院率，并减少新生儿巨大儿、高胆红素血症和住院率。
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