Kaur Gaganpreet, Raj Tilak, Kaur Navneet, Singh Narinder
Centre for Nanoscience & Nanotechnology (UIEAST), Panjab University, Chandigarh 160014, India.
Org Biomol Chem. 2015 Apr 28;13(16):4673-9. doi: 10.1039/c5ob00206k.
A pyrimidine-based sensor () has been synthesized through the facile one pot reaction of pyrrole-2-carboxaldehyde, 2-aminobenzimidazole and 1, 3-dimethylbarbituric acid in methanol using a few drops of HCl as a catalyst. Further, compound was fabricated into its fluorescent organic nanoparticles (FONPs) and characterized using DLS and SEM. The photophysical evaluation of the FONPs was done against bacteria and fungi. It was observed that the fluorescence intensity of the FONPs was selectively enhanced in the presence of the Gram -ve bacterium Pseudomonas aeruginosa with a detection limit of 46 CFU. To the best of our knowledge, this study is the first report on the use of the FONPs of pyrimidine derivative for the detection of Pseudomonas aeruginosa in various samples.
一种基于嘧啶的传感器（）通过吡咯 - 2 - 甲醛、2 - 氨基苯并咪唑和1,3 - 二甲基巴比妥酸在甲醇中，以几滴盐酸作为催化剂的简便一锅法反应合成。此外，该化合物被制备成其荧光有机纳米颗粒（FONPs），并使用动态光散射（DLS）和扫描电子显微镜（SEM）进行表征。对FONPs针对细菌和真菌进行了光物理评估。观察到在革兰氏阴性细菌铜绿假单胞菌存在下，FONPs的荧光强度选择性增强，检测限为46 CFU。据我们所知，本研究是关于使用嘧啶衍生物的FONPs检测各种样品中铜绿假单胞菌的首次报道。
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