水性助溶剂：一种用于喹唑啉酮衍生物绿色一锅法、多样化合成的高效且可重复使用的介质。
Aqueous hydrotrope: an efficient and reusable medium for a green one-pot, diversity-oriented synthesis of quinazolinone derivatives.
作者信息
Patil Amol, Barge Madhuri, Rashinkar Gajanan, Salunkhe Rajashri
机构信息
Department of Chemistry, Shivaji University, Kolhapur, 416004, MS, India.
出版信息
Mol Divers. 2015 Aug;19(3):435-45. doi: 10.1007/s11030-015-9580-8. Epub 2015 Mar 20.
PMID:25790788
Abstract
A library of quinazolinones was prepared by the one-pot three-component reaction of isatoic anhydride, ammonium salts/amines, and various electrophiles using aqueous hydrotropic solution as an efficient, economical, reusable, and green medium giving good to excellent yields of products in very short time. The method offers a versatile way for the development of diversity-oriented synthesis of quinazolinones.
摘要
通过邻苯二甲酸酐、铵盐/胺和各种亲电试剂的一锅三组分反应，以水性促溶溶液作为一种高效、经济、可重复使用的绿色介质，在极短时间内制备了喹唑啉酮文库，得到了产率良好至优异的产物。该方法为喹唑啉酮的多样性导向合成的发展提供了一种通用方法。
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