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以氧化锌反胶束为纳米反应器水相简便合成2,3-二氢喹唑啉-4(1H)-酮衍生物

An Aqueous Facile Synthesis of 2,3-Dihydroquinazolin-4(1H)-One Derivatives by Reverse Zinc Oxide Micelles as Nanoreactor.

作者信息

Mou Jie, Chen Ninghai, Zhao Yu, Qi Hao, Meng Sihan, Xiang Rui, Pei Dongsheng

机构信息

Jiangsu Key Laboratory of New drug and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China.

School of Pharmacy, Xuzhou Medical University, Xuzhou, China.

出版信息

Front Chem. 2020 Apr 24;8:239. doi: 10.3389/fchem.2020.00239. eCollection 2020.

DOI:10.3389/fchem.2020.00239
PMID:32391312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7193868/
Abstract

A green synthetic protocol has been developed for the efficient preparation of 2,3-dihydroquinazolin-4(1H)-one derivatives with excellent yield in aqueous media. Reverse zinc oxide micelles catalyzed the reactions efficiently and selectively as the hallow nanoreactor. Moreover, the catalyst was reusable without significant loss of catalytic efficiency. The notable advantages of the procedure are high yields and mild reaction conditions, simple operation, nonchromatographic purification, environmentally friendly and good versatile substrates.

摘要

已经开发出一种绿色合成方案，用于在水性介质中高效制备产率优异的2,3-二氢喹唑啉-4(1H)-酮衍生物。反向氧化锌胶束作为空心纳米反应器有效地且选择性地催化反应。此外，该催化剂可重复使用，而催化效率没有明显损失。该方法的显著优点是产率高、反应条件温和、操作简单、无需柱色谱纯化、环境友好且底物通用性好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/9fda5acc5fc1/fchem-08-00239-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/a1ff6ea57408/fchem-08-00239-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/f9c7013096fe/fchem-08-00239-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/1234d34eb12d/fchem-08-00239-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/3ffeab5694e3/fchem-08-00239-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/39904ba9d517/fchem-08-00239-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/bc2e8b88f3c5/fchem-08-00239-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/9fda5acc5fc1/fchem-08-00239-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/a1ff6ea57408/fchem-08-00239-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/f9c7013096fe/fchem-08-00239-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/1234d34eb12d/fchem-08-00239-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/3ffeab5694e3/fchem-08-00239-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/39904ba9d517/fchem-08-00239-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/bc2e8b88f3c5/fchem-08-00239-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7b/7193868/9fda5acc5fc1/fchem-08-00239-g0007.jpg

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