Zhu Xiaomei, Schwab Felix, Marcus Roy, Hetterich Holger, Theisen Daniel, Kramer Harald, Notohamiprodjo Mike, Schlett Christopher L, Nikolaou Konstantin, Reiser Maximilian F, Bamberg Fabian
Institute of Clinical Radiology, Ludwig-Maximilians-University Hospital, Marchioninistrasse 15, 81377 Munich, Germany; Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300, Guangzhou Road, 210029 Nanjing, Jiangsu, China.
Institute of Clinical Radiology, Ludwig-Maximilians-University Hospital, Marchioninistrasse 15, 81377 Munich, Germany.
Eur J Radiol. 2015 May;84(5):849-55. doi: 10.1016/j.ejrad.2015.02.016. Epub 2015 Feb 28.
To determine the feasibility of free-breathing, GRAPPA-based, real-time (RT) cine 3T cardiac magnetic resonance imaging (MRI) with high acceleration factors for the assessment of left-ventricular function in a cohort of patients as compared to conventional segmented cine imaging.
In this prospective cohort study, subjects with various cardiac conditions underwent MRI involving two RT cine sequences (high resolution and low resolution) and standard segmented cine imaging. Standard qualitative and quantitative parameters of left-ventricular function were quantified.
Among 25 subjects, 24 were included in the analysis (mean age: 50.5±21 years, 67% male, 25% with cardiomyopathy). RT cine derived quantitative parameters of volumes and left ventricular mass were strongly correlated with segmented cine imaging (intraclass correlation coefficient [ICC]: >0.72 for both RT cines) but correlation for peak ejection and filling rates were moderate to poor for both RT cines (ICC<0.40). Similarly, RT cines significantly underestimated peak ejection and filling rates (>103.2±178 ml/s). Among patient-related factors, heart rate was strongly predictive for deviation of measurements (p<0.05).
RT cine MRI at 3T is feasible for qualitative and quantitative assessment of left ventricular function for low and high-resolution sequences but results in significant underestimation of systolic function, peak ejection and filling rates.
与传统分段电影成像相比，确定在一组患者中使用基于GRAPPA的自由呼吸实时（RT）cine 3T心脏磁共振成像（MRI）及高加速因子评估左心室功能的可行性。
在这项前瞻性队列研究中，患有各种心脏疾病的受试者接受了MRI检查，包括两个RT cine序列（高分辨率和低分辨率）以及标准分段电影成像。对左心室功能的标准定性和定量参数进行了量化。
在25名受试者中，24名被纳入分析（平均年龄：50.5±21岁，67%为男性，25%患有心肌病）。RT cine得出的容积和左心室质量的定量参数与分段电影成像高度相关（两个RT cine的组内相关系数[ICC]均>0.72），但两个RT cine的射血峰值和充盈率的相关性中等至较差（ICC<0.40）。同样，RT cine显著低估了射血峰值和充盈率（>103.2±178 ml/s）。在与患者相关的因素中，心率对测量偏差具有强烈的预测性（p<0.05）。
3T的RT cine MRI对于低分辨率和高分辨率序列的左心室功能定性和定量评估是可行的，但会导致收缩功能、射血峰值和充盈率的显著低估。
