Picard J K, Hotta K, Feizi T
J Clin Pathol. 1985 Mar;38(3):320-6. doi: 10.1136/jcp.38.3.320.
In view of the anomalous expression of blood group and related antigens in the gastric mucosae of patients with malignant and premalignant diseases of the stomach, and the potential clinical value of their measurement, a preliminary study has been performed on the blood group antigens A, B, H, Lea, Leb, and I(Ma) in glycoprotein rich extracts of the resting and tetragastrin stimulated gastric juice of patients without evidence of gastric cancer. The aim has been to assess whether the antigenic profiles known to distinguish the gastric mucosae of secretors from those of non-secretors are reflected in the glycoproteins of gastric juice. Antigenic profiles which distinguish secretors from non-secretors were observed in the stimulated rather than the resting gastric juice as follows: the A, B or H antigens but not I(Ma) were strongly expressed in the glycoproteins of secretors, while I(Ma) was the antigen characteristic of non-secretors. On the other hand, there was considerable overlap in the Lea and Leb antigen values in the resting and stimulated gastric juice of secretors and non-secretors. Among these antigens, I(Ma) is known to appear as a neo-antigen in the gastric mucosae of secretors with malignant and premalignant diseases of the stomach. Thus this antigenic determinant is potentially a clinically useful marker in the gastric juice of 75% of the population who are secretors. The clinical value of the levels of this antigen in the gastric juice now deserves investigation.
鉴于胃癌及癌前疾病患者胃黏膜中血型及相关抗原的异常表达及其检测的潜在临床价值，我们对无胃癌证据患者的静息胃液和四肽胃泌素刺激胃液富含糖蛋白提取物中的血型抗原A、B、H、Lea、Leb和I(Ma)进行了初步研究。目的是评估已知区分分泌型和非分泌型胃黏膜的抗原谱是否反映在胃液糖蛋白中。在刺激胃液而非静息胃液中观察到区分分泌型和非分泌型的抗原谱如下：分泌型糖蛋白中强烈表达A、B或H抗原，但不表达I(Ma)，而I(Ma)是非分泌型的特征性抗原。另一方面，分泌型和非分泌型静息胃液和刺激胃液中Lea和Leb抗原值有相当大的重叠。在这些抗原中，已知I(Ma)在患有胃癌及癌前疾病的分泌型胃黏膜中作为新抗原出现。因此，这种抗原决定簇可能是75%分泌型人群胃液中一种临床上有用的标志物。该抗原在胃液中的水平的临床价值现在值得研究。
