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使用临床实际场景对剂量变形算法进行验证。

Validation of a dose warping algorithm using clinically realistic scenarios.

作者信息

Roussakis Y G, Dehghani H, Green S, Webster G J

机构信息

1 School of Computer Sciences, University of Birmingham, Edgbaston, Birmingham, UK.

出版信息

Br J Radiol. 2015 May;88(1049):20140691. doi: 10.1259/bjr.20140691. Epub 2015 Mar 20.

DOI:10.1259/bjr.20140691
PMID:25791569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4628476/
Abstract

OBJECTIVE

Dose warping following deformable image registration (DIR) has been proposed for interfractional dose accumulation. Robust evaluation workflows are vital to clinically implement such procedures. This study demonstrates such a workflow and quantifies the accuracy of a commercial DIR algorithm for this purpose under clinically realistic scenarios.

METHODS

12 head and neck (H&N) patient data sets were used for this retrospective study. For each case, four clinically relevant anatomical changes have been manually generated. Dose distributions were then calculated on each artificially deformed image and warped back to the original anatomy following DIR by a commercial algorithm. Spatial registration was evaluated by quantitative comparison of the original and warped structure sets, using conformity index and mean distance to conformity (MDC) metrics. Dosimetric evaluation was performed by quantitative comparison of the dose-volume histograms generated for the calculated and warped dose distributions, which should be identical for the ideal "perfect" registration of mass-conserving deformations.

RESULTS

Spatial registration of the artificially deformed image back to the planning CT was accurate (MDC range of 1-2 voxels or 1.2-2.4 mm). Dosimetric discrepancies introduced by the DIR were low (0.02 ± 0.03 Gy per fraction in clinically relevant dose metrics) with no statistically significant difference found (Wilcoxon test, 0.6 ≥ p ≥ 0.2).

CONCLUSION

The reliability of CT-to-CT DIR-based dose warping and image registration was demonstrated for a commercial algorithm with H&N patient data.

ADVANCES IN KNOWLEDGE

This study demonstrates a workflow for validation of dose warping following DIR that could assist physicists and physicians in quantifying the uncertainties associated with dose accumulation in clinical scenarios.

摘要

目的

已提出将可变形图像配准（DIR）后的剂量变形用于分次间剂量累积。稳健的评估工作流程对于临床实施此类程序至关重要。本研究展示了这样一种工作流程，并在临床实际场景下为此目的量化了一种商用DIR算法的准确性。

方法

本回顾性研究使用了12例头颈部（H&N）患者数据集。对于每个病例，手动生成了四种临床相关的解剖结构变化。然后在每个人工变形图像上计算剂量分布，并通过商用算法在DIR后将其变形回原始解剖结构。通过使用一致性指数和平均一致性距离（MDC）指标对原始和变形后的结构集进行定量比较来评估空间配准。通过对计算和变形后的剂量分布生成的剂量体积直方图进行定量比较来进行剂量学评估，对于质量守恒变形的理想“完美”配准，两者应相同。

结果

将人工变形图像空间配准回计划CT是准确的（MDC范围为1 - 2体素或1.2 - 2.4毫米）。DIR引入的剂量学差异较低（在临床相关剂量指标中每分次0.02±0.03 Gy），未发现统计学显著差异（Wilcoxon检验，0.6≥p≥0.2）。

结论

对于商用算法，利用H&N患者数据证明了基于CT到CT DIR的剂量变形和图像配准的可靠性。

知识进展

本研究展示了一种用于验证DIR后剂量变形的工作流程，可协助物理学家和医生量化临床场景中与剂量累积相关的不确定性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/e55e0ddbdd6a/bjr.20140691.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/82348195c33a/bjr.20140691.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/655b2e7b84a4/bjr.20140691.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/c43364bebf90/bjr.20140691.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/c1724b6b33eb/bjr.20140691.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/282d92399cde/bjr.20140691.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/e55e0ddbdd6a/bjr.20140691.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/82348195c33a/bjr.20140691.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/655b2e7b84a4/bjr.20140691.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/c43364bebf90/bjr.20140691.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/c1724b6b33eb/bjr.20140691.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/282d92399cde/bjr.20140691.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c7/4628476/e55e0ddbdd6a/bjr.20140691.g006.jpg

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Parotid glands dose-effect relationships based on their actually delivered doses: implications for adaptive replanning in radiation therapy of head-and-neck cancer.基于实际给予剂量的腮腺剂量-效应关系：对头颈癌放射治疗中自适应计划重订的意义。
Int J Radiat Oncol Biol Phys. 2013 Nov 15;87(4):676-82. doi: 10.1016/j.ijrobp.2013.07.040. Epub 2013 Sep 10.
3
On the need for comprehensive validation of deformable image registration, investigated with a novel 3-dimensional deformable dosimeter.
需要对三维形变剂量仪进行全面验证，本文对此进行了研究。
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4
A framework for deformable image registration validation in radiotherapy clinical applications.用于放射治疗临床应用中的可变形图像配准验证的框架。
J Appl Clin Med Phys. 2013 Jan 2;14(1):4066. doi: 10.1120/jacmp.v14i1.4066.
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The need for application-based adaptation of deformable image registration.基于应用的形变图像配准的调整需求。
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