Clerget Guillaume, Abel Yoann, Rederstorff Mathieu
Université de Lorraine, CNRS UMR 7365, IMoPA, 9 avenue de la Forêt de Haye, Vandoeuvre-lès-Nancy, 54506, France.
Methods Mol Biol. 2015;1296:3-9. doi: 10.1007/978-1-4939-2547-6_1.
The revolution of miRNA discovery, in the early 2000s, shed a new light in the exciting field of small non-coding RNAs. Since then, and owing to outstanding breakthroughs in RNomic techniques, novel small non-coding RNA families have been regularly discovered, e.g., piRNAs, tiRNAs, and many others.In this review, we provide a very succinct historical and functional overview on most prominent small non-coding RNA families.
21世纪初,微小RNA(miRNA)的发现掀起了一场革命,为令人兴奋的小非编码RNA领域带来了新的曙光。从那时起,由于核糖核酸组学技术的重大突破,新型小非编码RNA家族不断被发现,例如,PIWI相互作用RNA(piRNA)、tRNA衍生的小RNA(tiRNA)等等。在这篇综述中,我们对最著名的小非编码RNA家族进行了非常简洁的历史和功能概述。