Université de Lorraine, CNRS, IMoPA, F-54000 Nancy, France.
IGMM, CNRS, Université de Montpellier, Montpellier, France.
Methods Mol Biol. 2021;2300:3-9. doi: 10.1007/978-1-0716-1386-3_1.
The discovery of new classes of non-coding RNAs has always been preceded or accompanied by technological breakthroughs, and these outstanding progresses in transcriptomics approaches enabled to regularly add new members to the list. From the first detection of tRNAs, through the revolution of miRNAs discovery, to the recent identification of eRNAs or the identification of new functions for already known ncRNAs, this introductive review provides a very concise historical and functional overview of most prominent small regulatory non-coding RNA families.
新的非编码 RNA 类别的发现总是伴随着技术突破,转录组学方法的这些杰出进展使得人们能够定期将新成员添加到列表中。从最初的 tRNA 检测,到 miRNA 发现的革命,再到最近的 eRNA 鉴定或已经发现的 ncRNAs 的新功能鉴定,本篇综述简要概述了最主要的小调控非编码 RNA 家族的历史和功能。