Paz Eva, Sanz-Ruiz Pablo, Abenojar Juana, Vaquero-Martín Javier, Forriol Francisco, Del Real Juan Carlos
Institute for Research in Technology/Mechanical Engineering Department, Universidad Pontificia Comillas, Madrid, Spain.
Department of Traumatology and Orthopaedic Surgery, General University Hospital Gregorio Marañón, Madrid, Spain.
J Arthroplasty. 2015 Aug;30(8):1423-9. doi: 10.1016/j.arth.2015.02.040. Epub 2015 Mar 7.
Use of antibiotic-loaded bone cements is one of the most effective methods for the prevention and treatment of prosthetic joint infection. However, there is still controversy about the optimal combination and doses of antibiotics that provide the maximum antimicrobial effect without compromising cement properties. In this study, vancomycin and cefazolin were added to a bone cement (Palacos R+G). Antibiotic release, fluid absorption, and mechanical properties were evaluated under physiological conditions. The results show that the type of antibiotic selected has an important impact on cement properties. In this study, groups with cefazolin showed much higher elution than those containing the same concentration of vancomycin. In contrast, groups with cefazolin showed a lower strength than vancomycin groups.
使用载抗生素骨水泥是预防和治疗人工关节感染最有效的方法之一。然而，关于能在不影响骨水泥性能的前提下提供最大抗菌效果的抗生素最佳组合和剂量仍存在争议。在本研究中，将万古霉素和头孢唑林添加到一种骨水泥（Palacos R+G）中。在生理条件下对抗生素释放、液体吸收和力学性能进行了评估。结果表明，所选抗生素的类型对骨水泥性能有重要影响。在本研究中，含头孢唑林的组比含有相同浓度万古霉素的组洗脱率高得多。相比之下，含头孢唑林的组比万古霉素组强度低。
