背侧苍白球中多巴胺 D2/3 受体可利用度的不对称性与非肥胖健康男性的体重指数。
Asymmetry of Dopamine D2/3 Receptor Availability in Dorsal Putamen and Body Mass Index in Non-obese Healthy Males.
机构信息
Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 463-707, Korea.
Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 463-707, Korea. ; Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742, Korea. ; Advanced Institutes of Convergence Technology, Suwon 443-270, Korea.
出版信息
Exp Neurobiol. 2015 Mar;24(1):90-4. doi: 10.5607/en.2015.24.1.90. Epub 2015 Jan 21.
The dopaminergic system is involved in the regulation of food intake, which is crucial for the maintenance of body weight. We examined the relationship between striatal dopamine (DA) D2/3 receptor availability and body mass index (BMI) in 25 non-obese healthy male subjects using [(11)C]raclopride and positron emission tomography. None of [(11)C]raclopride binding potential (BP) values (measures of DA D2/3 receptor availability) in striatal subregions (dorsal caudate, dorsal putamen, and ventral striatum) in the left and right hemispheres was significantly correlated with BMI. However, there was a positive correlation between the right-left asymmetry index of [(11)C]raclopride BP in the dorsal putamen and BMI (r=0.43, p<0.05), suggesting that greater BMI is linked with higher receptor availability in the right dorsal putamen relative to the left in non-obese individuals. The present results, combined with previous findings, may also suggest neurochemical mechanisms underlying the regulation of food intake in non-obese individuals.
多巴胺能系统参与食物摄入的调节，这对于维持体重至关重要。我们使用[(11)C]raclopride 和正电子发射断层扫描技术，在 25 名非肥胖的健康男性受试者中研究了纹状体多巴胺（DA）D2/3 受体可用性与体重指数（BMI）之间的关系。左右半球纹状体亚区（背侧尾状核、背侧壳核和腹侧纹状体）中[(11)C]raclopride 结合的 BP 值（DA D2/3 受体可用性的测量值）与 BMI 均无显著相关性。然而，背侧壳核中[(11)C]raclopride BP 的左右不对称指数与 BMI 呈正相关（r=0.43，p<0.05），这表明非肥胖个体中右背侧壳核的受体可用性相对于左背侧壳核更高，与 BMI 更高有关。这些结果与之前的研究结果相结合，也可能提示了非肥胖个体中食物摄入调节的神经化学机制。
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