Fakour Youssef, Noormohammadpour Pedram, Ameri Hamed, Ehsani Amir Houshang, Mokhtari Leila, Khosrovanmehr Najmeh, Hoseini Nezhad Seyedeh Zahra
Assistant professor, Department of Psychiatry, Tehran University of Medical Sciences, Razi hospital, Tehran, Iran.
Assistant professor, Department of Dermatology, Tehran University of Medical Sciences, Razi hospital, Tehran, Iran.
Iran J Psychiatry. 2014 Oct;9(4):237-40.
Acne is the most common skin disease and isotretinoin is the most powerful drug among the various drugs used for its treatment, but it has some adverse effects. The aim of this study was to evaluate the effect of isotretinoin on depression and quality of life of a group of patients undergoing isotretinoin therapy before and after the treatment course.
In this prospective study, 98 patients with severe acne were enrolled consecutively and underwent isotretinoin therapy receiving 0.5 mg/kg/d of isotretinoin for 16 weeks. Isotretinoin effects on quality of life and depression were evaluated using Dermatology Life Quality Index (DLQI) and Beck Depression Inventory (BDI) questionnaires, respectively.
In this study, 98 patients suffering from severe acne (38 males and 60 females) were enrolled. Treatment of acne was associated with improvement of quality of life scores in both male and female patients (p = 0.001). Considering the cutoff value of 13 for mild depressive mood in the BDI score, in total, 48 (49%) of the enrolled patients (21 males and 33 females) had a mild depressive mood before the commencement of the treatment in this study. The analysis of before and after treatment BDI scores showed that the number of patients and also the mean score of BDI were increased in both male and female patients after the treatment (p<0.05).
Isotretinoin therapy improved the quality of life of patients suffering from acne, but depression was accentuated in the patients to some extent.
痤疮是最常见的皮肤病，异维甲酸是治疗痤疮的各类药物中效力最强的，但它有一些不良反应。本研究的目的是评估异维甲酸对一组接受异维甲酸治疗的患者在治疗疗程前后的抑郁及生活质量的影响。
在这项前瞻性研究中，连续纳入98例重度痤疮患者，接受异维甲酸治疗，剂量为0.5mg/kg/d，持续16周。分别使用皮肤病生活质量指数（DLQI）和贝克抑郁量表（BDI）问卷评估异维甲酸对生活质量和抑郁的影响。
本研究纳入了98例重度痤疮患者（38例男性和60例女性）。痤疮治疗与男性和女性患者生活质量评分的改善相关（p = 0.001）。考虑到BDI评分中轻度抑郁情绪的临界值为13，在本研究中，总共有48例（49%）纳入患者（21例男性和33例女性）在治疗开始前有轻度抑郁情绪。治疗前后BDI评分分析显示，治疗后男性和女性患者的患者数量以及BDI平均评分均增加（p<0.05）。
异维甲酸治疗改善了痤疮患者的生活质量，但在一定程度上加重了患者的抑郁。
