连续血流对终末器官功能的生理影响：左心室辅助装置当前时代的临床意义。
Physiological impact of continuous flow on end-organ function: clinical implications in the current era of left ventricular assist devices.
作者信息
Bhimaraj Arvind, Uribe Cesar, Suarez Erick E
机构信息
Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas.
出版信息
Methodist Debakey Cardiovasc J. 2015 Jan-Mar;11(1):12-7. doi: 10.14797/mdcj-11-1-12.
Abstract
The clinical era of continuous-flow left ventricular assist devices has debunked many myths about the dire need of a pulse for human existence. While this therapy has been documented to provide a clear survival benefit in end-stage heart failure patients, we are now faced with certain morbidity challenges that as of yet have no easy mechanistic physiological explanation. The effect of physiological changes on end-organ function in patients supported by continuous-flow ventricular assist devices may offer insight into some of these morbidities. We therefore present a review of current evidence documenting the impact of continuous flow on end-organ function.
摘要
连续流左心室辅助装置的临床应用时代打破了许多关于人类生存迫切需要脉搏的误解。虽然已证明这种疗法能为终末期心力衰竭患者带来明显的生存益处，但我们现在面临一些发病挑战，而目前尚无简单的机制性生理学解释。生理变化对接受连续流心室辅助装置支持的患者终末器官功能的影响，可能有助于深入了解其中一些发病情况。因此，我们对记录连续流对终末器官功能影响的现有证据进行综述。
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