在小鼠细胞中阻止RNA积累的c-mos（大鼠）上游序列不抑制体外转录。
Sequences upstream of c-mos(rat) that block RNA accumulation in mouse cells do not inhibit in vitro transcription.
作者信息
van der Hoorn F A, Müller V, Pizer L I
出版信息
Mol Cell Biol. 1985 Feb;5(2):406-9. doi: 10.1128/mcb.5.2.406-409.1985.
Abstract
An unusual feature of the c-mos oncogene is the lack of expression in mouse tissues. Recombinant plasmids that contain the strong adenovirus late promoter and different amounts of cellular DNA 5' to c-mos(rat) were constructed and tested in transfection and transcription assays. The cellular sequences inhibit RNA accumulation in mouse but not human cells and do not inhibit in vitro transcription of the plasmid DNAs.
摘要
c-mos癌基因的一个不同寻常的特征是在小鼠组织中缺乏表达。构建了含有强腺病毒晚期启动子以及c-mos（大鼠）5'端不同量细胞DNA的重组质粒，并在转染和转录分析中进行了测试。细胞序列抑制小鼠细胞而非人类细胞中的RNA积累，并且不抑制质粒DNA的体外转录。
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