• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在小鼠细胞中阻止RNA积累的c-mos（大鼠）上游序列不抑制体外转录。

Sequences upstream of c-mos(rat) that block RNA accumulation in mouse cells do not inhibit in vitro transcription.

作者信息

van der Hoorn F A, Müller V, Pizer L I

出版信息

Mol Cell Biol. 1985 Feb;5(2):406-9. doi: 10.1128/mcb.5.2.406-409.1985.

DOI:10.1128/mcb.5.2.406-409.1985
PMID:2579322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC366724/
Abstract

An unusual feature of the c-mos oncogene is the lack of expression in mouse tissues. Recombinant plasmids that contain the strong adenovirus late promoter and different amounts of cellular DNA 5' to c-mos(rat) were constructed and tested in transfection and transcription assays. The cellular sequences inhibit RNA accumulation in mouse but not human cells and do not inhibit in vitro transcription of the plasmid DNAs.

摘要

c-mos癌基因的一个不同寻常的特征是在小鼠组织中缺乏表达。构建了含有强腺病毒晚期启动子以及c-mos（大鼠）5'端不同量细胞DNA的重组质粒，并在转染和转录分析中进行了测试。细胞序列抑制小鼠细胞而非人类细胞中的RNA积累，并且不抑制质粒DNA的体外转录。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a427/366724/ed9414cbfde3/molcellb00098-0144-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a427/366724/ca77ea20a87f/molcellb00098-0143-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a427/366724/eabf4edb1806/molcellb00098-0144-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a427/366724/ed9414cbfde3/molcellb00098-0144-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a427/366724/ca77ea20a87f/molcellb00098-0143-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a427/366724/eabf4edb1806/molcellb00098-0144-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a427/366724/ed9414cbfde3/molcellb00098-0144-b.jpg

相似文献

1
Sequences upstream of c-mos(rat) that block RNA accumulation in mouse cells do not inhibit in vitro transcription.在小鼠细胞中阻止RNA积累的c-mos（大鼠）上游序列不抑制体外转录。
Mol Cell Biol. 1985 Feb;5(2):406-9. doi: 10.1128/mcb.5.2.406-409.1985.
2
Sequences upstream from the mouse c-mos oncogene may function as a transcription termination signal.小鼠c-mos癌基因上游的序列可能起到转录终止信号的作用。
DNA. 1986 Aug;5(4):289-98. doi: 10.1089/dna.1986.5.289.
3
The repressor sequence upstream of c-mos acts neither as polyadenylation site nor as transcription termination region.c-mos上游的阻遏物序列既不作为聚腺苷酸化位点，也不作为转录终止区域。
Nucleic Acids Res. 1986 Nov 25;14(22):8771-83. doi: 10.1093/nar/14.22.8771.
4
Identification of a negative regulatory element that inhibits c-mos transcription in somatic cells.在体细胞中抑制c-mos转录的负调控元件的鉴定。
Mol Cell Biol. 1992 May;12(5):2029-36. doi: 10.1128/mcb.12.5.2029-2036.1992.
5
c-mos expression in mouse oocytes is controlled by initiator-related sequences immediately downstream of the transcription initiation site.小鼠卵母细胞中c-mos的表达受转录起始位点下游紧邻的起始子相关序列调控。
Mol Cell Biol. 1991 Oct;11(10):5190-6. doi: 10.1128/mcb.11.10.5190-5196.1991.
6
Mouse c-mos oncogene activation is prevented by upstream sequences.小鼠c-mos癌基因的激活受到上游序列的抑制。
Proc Natl Acad Sci U S A. 1984 Dec;81(24):7817-21. doi: 10.1073/pnas.81.24.7817.
7
Analysis of the transforming potential of the human homolog of mos.
Cell. 1986 Aug 29;46(5):785-94. doi: 10.1016/0092-8674(86)90354-5.
8
DNA sequences downstream of the adenovirus type 2 fiber polyadenylation site contain transcription termination signals.腺病毒2型纤维多聚腺苷酸化位点下游的DNA序列包含转录终止信号。
J Virol. 1987 Sep;61(9):2770-6. doi: 10.1128/JVI.61.9.2770-2776.1987.
9
Expression of c-mos proto-oncogene transcripts in mouse tissues.c-mos原癌基因转录本在小鼠组织中的表达。
Nature. 1985;315(6019):516-8. doi: 10.1038/315516a0.
10
Different promoter elements are required for the induced expression of c-fos and c-jun proto-oncogenes by the v-mos oncogene product.
New Biol. 1990 Feb;2(2):143-50.

引用本文的文献

1
Identification of a cis acting element responsible for muscle specific expression of the c-mos protooncogene.鉴定负责原癌基因c-mos肌肉特异性表达的顺式作用元件。
Nucleic Acids Res. 1993 Feb 11;21(3):695-702. doi: 10.1093/nar/21.3.695.
2
Differential expression of mouse beta/goat beta c, mouse beta/goat beta F, and mouse beta/goat epsilon II hybrid globin genes in murine erythroleukemia cells.小鼠β/山羊βc、小鼠β/山羊βF和小鼠β/山羊εII杂交珠蛋白基因在鼠红细胞白血病细胞中的差异表达。
Mol Cell Biol. 1986 Nov;6(11):3873-83. doi: 10.1128/mcb.6.11.3873-3883.1986.
3
Repression mediates cell-type-specific expression of the rat growth hormone gene.

本文引用的文献

1
In vitro transcription of adenovirus.腺病毒的体外转录
J Virol. 1981 Dec;40(3):703-19. doi: 10.1128/JVI.40.3.703-719.1981.
2
A catalogue of splice junction sequences.剪接连接序列目录。
Nucleic Acids Res. 1982 Jan 22;10(2):459-72. doi: 10.1093/nar/10.2.459.
3
Identification of a RNA polymerase II initiation site in the long terminal repeat of Moloney murine leukemia viral DNA.莫洛尼鼠白血病病毒DNA长末端重复序列中RNA聚合酶II起始位点的鉴定。
阻遏作用介导大鼠生长激素基因的细胞类型特异性表达。
Proc Natl Acad Sci U S A. 1986 Nov;83(21):8283-7. doi: 10.1073/pnas.83.21.8283.
4
The repressor sequence upstream of c-mos acts neither as polyadenylation site nor as transcription termination region.c-mos上游的阻遏物序列既不作为聚腺苷酸化位点，也不作为转录终止区域。
Nucleic Acids Res. 1986 Nov 25;14(22):8771-83. doi: 10.1093/nar/14.22.8771.
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5411-5. doi: 10.1073/pnas.78.9.5411.
4
In vitro methylation of specific regions of the cloned Moloney sarcoma virus genome inhibits its transforming activity.克隆的莫洛尼氏肉瘤病毒基因组特定区域的体外甲基化会抑制其转化活性。
Mol Cell Biol. 1983 Mar;3(3):305-14. doi: 10.1128/mcb.3.3.305-314.1983.
5
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.从分离的哺乳动物细胞核的可溶性提取物中，RNA聚合酶II进行准确的转录起始。
Nucleic Acids Res. 1983 Mar 11;11(5):1475-89. doi: 10.1093/nar/11.5.1475.
6
From c-fos to v-fos.从原癌基因c-fos到病毒癌基因v-fos。
Nature. 1984;308(5957):317. doi: 10.1038/308317a0.
7
c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene.c-fos蛋白可诱导细胞转化：一种细胞癌基因激活的新机制。
Cell. 1984 Jan;36(1):51-60. doi: 10.1016/0092-8674(84)90073-4.
8
Molecular cloning of unintegrated Moloney mouse sarcoma virus DNA in bacteriophage lambda.莫洛尼氏小鼠肉瘤病毒未整合DNA在噬菌体λ中的分子克隆
Proc Natl Acad Sci U S A. 1980 Apr;77(4):1773-7. doi: 10.1073/pnas.77.4.1773.
9
Cellular oncogenes and retroviruses.细胞癌基因与逆转录病毒。
Annu Rev Biochem. 1983;52:301-54. doi: 10.1146/annurev.bi.52.070183.001505.
10
Molecularly cloned c-mos(rat) is biologically active.分子克隆的c-mos（大鼠）具有生物活性。
EMBO J. 1982;1(11):1313-7. doi: 10.1002/j.1460-2075.1982.tb01316.x.