Sutherland I A
a AgResearch Ltd., Grasslands Research Centre , Private Bag 11008, Palmerston North , New Zealand.
N Z Vet J. 2015 Jul;63(4):183-7. doi: 10.1080/00480169.2015.1019947. Epub 2015 May 13.
There have been a number of significant advances in recent years to the theory and practice of managing anthelmintic resistance in sheep in Australasia. The general principles of resistance management are, firstly identification and mitigation of high-risk practices, secondly using effective anthelmintics, and thirdly maintaining a refuge of unselected parasites. The first of these principles has been updated recently with the findings from a series of farm-based trials in New Zealand, in which the economic benefits of both short- and long-acting anthelmintic treatments in ewes pre-lambing were found to be inconsistent and not always positive. There have also been significant changes to the second principle, particularly given the introduction of new active families onto the market. Evidence continues to favour the use of combination products to maximise efficacy and delay the onset of treatment-failure. Many farmers have readily accepted the effectiveness of maintaining a refuge of unselected parasites; the challenge for researchers and advisers is now to improve adoption of properly designed and implemented resistance management programmes. A recently completed education programme in New Zealand has demonstrated that when this is achieved, then anthelmintic resistance can be controlled, and in many cases reduced in severity.
近年来，在澳大利亚和新西兰，绵羊抗蠕虫药耐药性管理的理论和实践取得了一些重大进展。耐药性管理的一般原则是：首先，识别并减少高风险做法；其次，使用有效的抗蠕虫药；第三，保留未经选择的寄生虫庇护所。随着新西兰一系列农场试验结果的公布，上述第一个原则最近得到了更新，试验发现，在产羔前对母羊进行短效和长效抗蠕虫药治疗的经济效益并不一致，而且并非总是积极的。第二个原则也发生了重大变化，特别是考虑到市场上引入了新的活性药物类别。有证据继续支持使用复方产品，以最大限度地提高疗效并延缓治疗失败的发生。许多农民欣然接受保留未经选择的寄生虫庇护所的有效性；研究人员和顾问目前面临的挑战是，提高对设计合理且实施得当的耐药性管理方案的采用率。新西兰最近完成的一项教育计划表明，当做到这一点时，抗蠕虫药耐药性就可以得到控制，而且在许多情况下，其严重程度会降低。
