Blaize A Nicole, Breslin Emily, Donkin Shawn S, Cabot Ryan, Pearson Kevin J, Newcomer Sean C
1Department of Health and Kinesiology, Purdue University, West Lafayette, IN; 2Department of Animal Science, Purdue University, West Lafayette, IN; 3Graduate Center for Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY; and 4Department of Kinesiology, California State University San Marcos, San Marcos, CA.
Med Sci Sports Exerc. 2015 Nov;47(11):2340-6. doi: 10.1249/MSS.0000000000000665.
Research has revealed the role of adverse behaviors during pregnancy on metabolic and cardiovascular health outcomes in offspring. However, minimal attention has been focused on positive prenatal behaviors, such as exercise, and the effect on offspring health outcomes. The objective of this investigation was to test the hypothesis that mothers who voluntarily exercise during pregnancy would improve endothelial function in offspring from exercising compared with sedentary mothers.
Female Sprague Dawley rats were divided into sedentary (n = 10) or exercise (n = 9) groups with, the exercise group having voluntary access to a running wheel throughout gestation. Litter characteristics (weight and size) were taken 1 d after birth. After weaning, offspring were placed in sedentary cages where they remained until 4 or 8 months of age. Offspring food consumption and cage activity were assessed during a 72-h interval at 2, 4, 6, and 8 months of age. The abdominal aortas of offspring were harvested at 4 or 8 months of age, and vascular function was assessed using cumulative doses of endothelium-dependent (acetylcholine/10(-10)-10(-4) M) and independent (sodium nitroprusside/10(-10)-10(-4) M) vasodilators.
There were no significant differences in litter size and litter weight at weaning between the sedentary and exercise groups. Food consumption and wheel running activity did not differ between the sedentary and exercise offspring at 2, 4, 6, or 8 months of age. Vasorelaxation response to acetylcholine or sodium nitroprusside did not differ between the offspring from sedentary and exercise dams.
Maternal voluntary wheel running during pregnancy does not significantly alter behavior or vascular function in adult offspring.
研究揭示了孕期不良行为对后代代谢和心血管健康结局的影响。然而，对于积极的产前行为，如运动及其对后代健康结局的影响关注极少。本研究的目的是检验以下假设：与久坐不动的母亲相比，孕期自愿运动的母亲所生后代的内皮功能会因运动而得到改善。
将雌性斯普拉格-道利大鼠分为久坐组（n = 10）和运动组（n = 9），运动组在整个妊娠期可自愿使用跑步轮。出生1天后记录窝仔特征（体重和大小）。断奶后，将后代置于久坐的笼子中，直至4或8月龄。在后代2、4、6和8月龄时，在72小时内评估其食物消耗量和笼内活动情况。在4或8月龄时采集后代的腹主动脉，使用累积剂量的内皮依赖性（乙酰胆碱/10（-10）-10（-4）M）和非内皮依赖性（硝普钠/10（-10）-10（-4）M）血管舒张剂评估血管功能。
久坐组和运动组断奶时的窝仔大小和窝仔体重无显著差异。久坐组和运动组的后代在2、4、6或8月龄时的食物消耗量和跑步轮活动情况没有差异。久坐组和运动组母鼠所产后代对乙酰胆碱或硝普钠的血管舒张反应没有差异。
孕期母鼠自愿跑步对成年后代的行为或血管功能没有显著影响。
