Eclarinal Jesse D, Zhu Shaoyu, Baker Maria S, Piyarathna Danthasinghe B, Coarfa Cristian, Fiorotto Marta L, Waterland Robert A
U.S. Department of Agriculture/Agricultural Research Service (USDA/ARS) Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA;
Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas USA; and.
FASEB J. 2016 Jul;30(7):2541-8. doi: 10.1096/fj.201500018R. Epub 2016 Mar 31.
Previous rodent studies have shown that maternal voluntary exercise during pregnancy leads to metabolic changes in adult offspring. We set out to test whether maternal voluntary exercise during pregnancy also induces persistent changes in voluntary physical activity in the offspring. Adult C57BL/6J female mice were randomly assigned to be caged with an unlocked (U) or locked (L) running wheel before and during pregnancy. Maternal running behavior was monitored during pregnancy, and body weight, body composition, food intake, energy expenditure, total cage activity, and running wheel activity were measured in the offspring at various ages. U offspring were slightly heavier at birth, but no group differences in body weight or composition were observed at later ages (when mice were caged without access to running wheels). Consistent with our hypothesis, U offspring were more physically active as adults. This effect was observed earlier in female offspring (at sexual maturation). Remarkably, at 300 d of age, U females achieved greater fat loss in response to a 3-wk voluntary exercise program. Our findings show for the first time that maternal physical activity during pregnancy affects the offspring's lifelong propensity for physical activity and may have important implications for combating the worldwide epidemic of physical inactivity and obesity.-Eclarinal, J. D., Zhu, S., Baker, M. S., Piyarathna, D. B., Coarfa, C., Fiorotto, M. L., Waterland, R. A. Maternal exercise during pregnancy promotes physical activity in adult offspring.
先前的啮齿动物研究表明，孕期母体进行自主运动可导致成年后代出现代谢变化。我们着手测试孕期母体进行自主运动是否也会引起后代自主身体活动的持续变化。成年C57BL/6J雌性小鼠在怀孕前及怀孕期间被随机分配至装有未锁（U）或锁上（L）跑轮的笼子中饲养。孕期监测母体的跑步行为，并在后代不同年龄阶段测量其体重、身体组成、食物摄入量、能量消耗、总笼内活动量及跑轮活动量。U组后代出生时体重略重，但在后期（小鼠被关在无跑轮的笼子里时）未观察到体重或身体组成方面的组间差异。与我们的假设一致，U组后代成年后身体活动更为活跃。这种效应在雌性后代（性成熟时）出现得更早。值得注意的是，在300日龄时，U组雌性小鼠在为期3周的自主运动计划后实现了更多的脂肪减少。我们的研究结果首次表明，孕期母体的身体活动会影响后代一生的身体活动倾向，这可能对对抗全球范围内的身体不活动和肥胖流行具有重要意义。——埃克拉利纳尔，J. D.，朱，S.，贝克，M. S.，皮亚拉特纳达，D. B.，科尔法，C.，菲奥罗托，M. L.，沃特兰，R. A. 孕期母体运动促进成年后代的身体活动。
