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Phase I/II study of melphalan, prednisone and lenalidomide combination for patients with newly diagnosed multiple myeloma who are not candidates for stem cell transplantation.

作者信息

Roy V, Stewart A K, Bergsagel P L, Dispenzieri A, Laumann K, Allred J, Lacy M Q, Fonseca R, Reeder C B, Kumar S, Rivera C E, Gertz M A, Buadi F K, Hayman S R, Rajkumar S V

机构信息

Hematology-Oncology, Mayo Clinic, Jacksonville, FL, USA.

Hematology, Mayo Clinic, Scottsdale, AZ, USA.

出版信息

Blood Cancer J. 2015 Mar 20;5(3):e294. doi: 10.1038/bcj.2015.23.

DOI:10.1038/bcj.2015.23
PMID:25794130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4382664/
Abstract
摘要

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1
Phase I/II study of melphalan, prednisone and lenalidomide combination for patients with newly diagnosed multiple myeloma who are not candidates for stem cell transplantation.美法仑、泼尼松和来那度胺联合方案用于不适宜进行干细胞移植的新诊断多发性骨髓瘤患者的I/II期研究
Blood Cancer J. 2015 Mar 20;5(3):e294. doi: 10.1038/bcj.2015.23.
2
Autologous transplantation and maintenance therapy in multiple myeloma.自体移植和多发性骨髓瘤的维持治疗。
N Engl J Med. 2014 Sep 4;371(10):895-905. doi: 10.1056/NEJMoa1402888.
3
Melphalan, prednisone, and lenalidomide treatment for newly diagnosed myeloma: a report from the GIMEMA--Italian Multiple Myeloma Network.美法仑、泼尼松和来那度胺治疗新诊断的骨髓瘤：来自GIMEMA（意大利多发性骨髓瘤网络）的报告
J Clin Oncol. 2007 Oct 1;25(28):4459-65. doi: 10.1200/JCO.2007.12.3463. Epub 2007 Sep 4.
4
Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 trial.美法仑、泼尼松联合沙利度胺治疗75岁以上新诊断多发性骨髓瘤患者的疗效：IFM 01/01试验
J Clin Oncol. 2009 Aug 1;27(22):3664-70. doi: 10.1200/JCO.2008.21.0948. Epub 2009 May 18.
5
Continuous lenalidomide treatment for newly diagnosed multiple myeloma.来那度胺持续治疗新诊断的多发性骨髓瘤。
N Engl J Med. 2012 May 10;366(19):1759-69. doi: 10.1056/NEJMoa1112704.
6
Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: a randomized controlled trial.硼替佐米-马法兰-泼尼松-沙利度胺序贯硼替佐米-沙利度胺维持治疗与硼替佐米-马法兰-泼尼松方案治疗初治多发性骨髓瘤的随机对照研究
J Clin Oncol. 2010 Dec 1;28(34):5101-9. doi: 10.1200/JCO.2010.29.8216. Epub 2010 Oct 12.
7
Lenalidomide plus melphalan without prednisone for previously untreated older patients with multiple myeloma: a phase II trial.来那度胺联合美法仑，不使用泼尼松，治疗未经治疗的多发性骨髓瘤老年患者：一项 II 期试验。
Clin Lymphoma Myeloma Leuk. 2013 Feb;13(1):19-24. doi: 10.1016/j.clml.2012.08.009. Epub 2012 Nov 7.
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Lenalidomide in myeloma--a high-maintenance friend.来那度胺治疗骨髓瘤——一位需要长期维持治疗的帮手
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Lenalidomide-prednisone induction followed by lenalidomide-melphalan-prednisone consolidation and lenalidomide-prednisone maintenance in newly diagnosed elderly unfit myeloma patients.来那度胺-泼尼松诱导治疗后继以来那度胺-马法兰-泼尼松巩固治疗及来那度胺-泼尼松维持治疗用于新诊断的不适合移植的老年骨髓瘤患者。
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10
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Haematologica. 2015 Jun;100(6):826-33. doi: 10.3324/haematol.2014.120121. Epub 2015 Mar 13.

引用本文的文献

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Venous thromboembolism risk with contemporary lenalidomide-based regimens despite thromboprophylaxis in multiple myeloma: A systematic review and meta-analysis.尽管在多发性骨髓瘤中使用了抗凝药物，但当代来那度胺为基础的治疗方案仍存在静脉血栓栓塞风险：一项系统评价和荟萃分析。
Cancer. 2020 Apr 15;126(8):1640-1650. doi: 10.1002/cncr.32682. Epub 2020 Jan 8.
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Myeloma today: Disease definitions and treatment advances.多发性骨髓瘤现状：疾病定义和治疗进展。
Am J Hematol. 2016 Jan;91(1):90-100. doi: 10.1002/ajh.24236.
3
Multiple Myeloma, Version 2.2016: Clinical Practice Guidelines in Oncology.多发性骨髓瘤，2016年第2版：肿瘤学临床实践指南
J Natl Compr Canc Netw. 2015 Nov;13(11):1398-435. doi: 10.6004/jnccn.2015.0167.
4
Addition of lenalidomide to melphalan in the treatment of newly diagnosed multiple myeloma: the National Cancer Institute of Canada Clinical Trials Group MY.11 trial.来那度胺联合马法兰治疗新诊断多发性骨髓瘤：加拿大国家癌症研究所临床试验组 MY.11 试验。
Curr Oncol. 2007 Apr;14(2):61-5. doi: 10.3747/co.2007.107.

本文引用的文献

1
Treatment of multiple myeloma.多发性骨髓瘤的治疗。
Nat Rev Clin Oncol. 2011 Apr 26;8(8):479-91. doi: 10.1038/nrclinonc.2011.63.
2
Rates of venous thromboembolism in multiple myeloma patients undergoing immunomodulatory therapy with thalidomide or lenalidomide: a systematic review and meta-analysis.来那度胺或沙利度胺治疗的多发性骨髓瘤患者的静脉血栓栓塞发生率：系统评价和荟萃分析。
J Thromb Haemost. 2011 Apr;9(4):653-63. doi: 10.1111/j.1538-7836.2011.04215.x.
3
Melphalan and prednisone versus melphalan, prednisone and thalidomide for elderly and/or transplant ineligible patients with multiple myeloma: a meta-analysis.来那度胺联合马法兰、泼尼松与马法兰、泼尼松治疗不适合移植的老年多发性骨髓瘤患者的疗效比较：一项荟萃分析。
Leukemia. 2011 Apr;25(4):689-96. doi: 10.1038/leu.2010.313. Epub 2011 Jan 14.
4
Addition of thalidomide to oral melphalan/prednisone in patients with multiple myeloma not eligible for transplantation: results of a randomized trial from the Turkish Myeloma Study Group.来那度胺联合口服美法仑/泼尼松治疗不适合移植的多发性骨髓瘤患者：来自土耳其骨髓瘤研究组的一项随机试验结果。
Eur J Haematol. 2011 Jan;86(1):16-22. doi: 10.1111/j.1600-0609.2010.01524.x. Epub 2010 Nov 22.
5
Lenalidomide plus dexamethasone versus thalidomide plus dexamethasone in newly diagnosed multiple myeloma: a comparative analysis of 411 patients.来那度胺联合地塞米松与沙利度胺联合地塞米松治疗初诊多发性骨髓瘤的比较分析：411 例患者的对比分析。
Blood. 2010 Feb 18;115(7):1343-50. doi: 10.1182/blood-2009-08-239046. Epub 2009 Dec 11.
6
Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 trial.美法仑、泼尼松联合沙利度胺治疗75岁以上新诊断多发性骨髓瘤患者的疗效：IFM 01/01试验
J Clin Oncol. 2009 Aug 1;27(22):3664-70. doi: 10.1200/JCO.2008.21.0948. Epub 2009 May 18.
7
Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.硼替佐米联合美法仑和泼尼松用于多发性骨髓瘤的初始治疗。
N Engl J Med. 2008 Aug 28;359(9):906-17. doi: 10.1056/NEJMoa0801479.
8
Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial.美法仑、泼尼松联合沙利度胺与单纯美法仑和泼尼松或减低强度自体干细胞移植治疗老年多发性骨髓瘤患者的疗效比较（IFM 99 - 06）：一项随机试验
Lancet. 2007 Oct 6;370(9594):1209-18. doi: 10.1016/S0140-6736(07)61537-2.
9
International uniform response criteria for multiple myeloma.多发性骨髓瘤的国际统一反应标准。
Leukemia. 2006 Sep;20(9):1467-73. doi: 10.1038/sj.leu.2404284. Epub 2006 Jul 20.
10
Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial.口服美法仑和泼尼松化疗加沙利度胺与单纯美法仑和泼尼松用于老年多发性骨髓瘤患者的比较：随机对照试验
Lancet. 2006 Mar 11;367(9513):825-31. doi: 10.1016/S0140-6736(06)68338-4.