Koukkou M, Lehmann D, Wackermann J, Dvorak I, Henggeler B
University Hospital of Psychiatry, Bern, Switzerland.
Biol Psychiatry. 1993 Mar 15;33(6):397-407. doi: 10.1016/0006-3223(93)90167-c.
The dimensional complexity of left temporal-parietal and parietal-occipital electroencephalographic (EEG) recordings was assessed by computing the correlation dimension during 20 sec in six recording conditions from 15 first-episode acute schizophrenics before medication, 12 other medication-free individuals clinically and socially remitted after a first schizophrenic episode, 17 medication-free neurotics and 17 controls. The correlation dimension of the temporal-parietal EEG differed between groups [analysis of variance (ANOVA)] (p < 0.004), whereas neurotics (different from schizophrenics at p < 0.002) and remitted schizophrenics showed intermediate values. There was no overall significant difference between groups in the parietal-occipital EEG. Differences of the correlation dimension of the temporal-parietal versus the parietal-occipital EEG were significant between groups (ANOVA p < 0.05); first-episode schizophrenics differed from controls (p < 0.002) and remitted patients (p < 0.08). Increased dimensional complexity of schizophrenic EEG was found in one of two examined brain regions. The higher dimensional complexity of functional brain mechanisms in schizophrenics versus normals is reminiscent of the loosened organization of thought, and of suggestions of certain superior abilities in the patients.
通过计算15名未用药的首发急性精神分裂症患者、12名首次精神分裂症发作后临床和社会功能已缓解的未用药个体、17名未用药的神经症患者以及17名对照组在六种记录条件下20秒内的关联维数，评估了左颞顶叶和顶枕叶脑电图（EEG）记录的维度复杂性。颞顶叶脑电图的关联维数在各组之间存在差异[方差分析（ANOVA）]（p<0.004），而神经症患者（与精神分裂症患者相比，p<0.002）和缓解期精神分裂症患者显示出中间值。顶枕叶脑电图在各组之间没有总体显著差异。颞顶叶与顶枕叶脑电图关联维数的差异在各组之间具有显著性（ANOVA，p<0.05）；首发精神分裂症患者与对照组（p<0.002）和缓解期患者（p<0.08）存在差异。在两个被检查的脑区之一中发现精神分裂症患者脑电图的维度复杂性增加。与正常人相比，精神分裂症患者功能性脑机制的维度复杂性更高，这让人联想到思维组织的松散，以及患者某些超常能力的迹象。
