Gurbuz Irem, Chiquet-Ehrismann Ruth
Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland; University of Basel, Faculty of Science, Basel, Switzerland.
Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland; University of Basel, Faculty of Science, Basel, Switzerland.
Int J Biochem Cell Biol. 2015 May;62:142-6. doi: 10.1016/j.biocel.2015.03.007. Epub 2015 Mar 17.
The matricellular protein WISP1 is a member of the CCN protein family. It is induced by WNT1 and is a downstream target of β-catenin. WISP1 is expressed during embryonic development, wound healing and tissue repair. Aberrant WISP1 expression is associated with various pathologies including osteoarthritis, fibrosis and cancer. Its role in tumor progression and clinical outcome makes WISP1 an emerging candidate for the detection and treatment of tumors.
基质细胞蛋白WISP1是CCN蛋白家族的成员。它由WNT1诱导产生，是β-连环蛋白的下游靶点。WISP1在胚胎发育、伤口愈合和组织修复过程中表达。WISP1表达异常与多种病理状况相关，包括骨关节炎、纤维化和癌症。其在肿瘤进展和临床结果中的作用使WISP1成为肿瘤检测和治疗的一个新兴候选物。
