Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No. 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, China.
Center of Scientific Research, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
J Transl Med. 2019 Jan 16;17(1):28. doi: 10.1186/s12967-019-1769-7.
Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression of a broad spectrum of human cancers. Mounting studies have identified that WISP proteins (WISP1-3) exert different biological functions in various human malignancies. Emerging evidence indicates that WISP proteins are critically involved in cell proliferation, apoptosis, invasion and metastasis in cancers. Because the understanding of a direct function of WISP proteins in cancer development and progression has begun to emerge, in this review article, we describe the physiological function of WISP proteins in a variety of human cancers. Moreover, we highlight the current understanding of how the WISP protein is involved in tumorigenesis and cancer progression. Furthermore, we discuss that targeting WISP proteins could be a promising strategy for the treatment of human cancers. Hence, the regulation of WISP proteins could improve treatments for cancer patients.
越来越多的证据表明，属于 CCN 生长因子家族成员的 WNT1 诱导信号通路蛋白 (WISP) 基因在多种人类癌症的发生和进展中起着关键作用。越来越多的研究表明，WISP 蛋白 (WISP1-3) 在各种人类恶性肿瘤中发挥不同的生物学功能。新出现的证据表明，WISP 蛋白在癌症中的细胞增殖、凋亡、浸润和转移中起着关键作用。由于人们开始了解 WISP 蛋白在癌症发展和进展中的直接功能，在这篇综述文章中，我们描述了 WISP 蛋白在多种人类癌症中的生理功能。此外，我们强调了目前对 WISP 蛋白如何参与肿瘤发生和癌症进展的理解。此外，我们还讨论了靶向 WISP 蛋白可能是治疗人类癌症的一种有前途的策略。因此，WISP 蛋白的调节可以改善癌症患者的治疗效果。
