Alkhalaf Lona M, Ryan Katherine S
Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 2K9, Canada.
Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 2K9, Canada.
Chem Biol. 2015 Mar 19;22(3):317-28. doi: 10.1016/j.chembiol.2015.02.005.
Tryptophan, the most chemically complex and the least abundant of the 20 common proteinogenic amino acids, is a biosynthetic precursor to a large number of complex microbial natural products. Many of these molecules are promising scaffolds for drug discovery and development. The chemical features of tryptophan, including its ability to undergo enzymatic modifications at almost every atom in its structure and its propensity to undergo spontaneous, non-enzyme catalyzed chemistry, make it a unique biological precursor for the generation of chemical complexity. Here, we review the pathways that enable incorporation of tryptophan into complex metabolites in bacteria, with a focus on recently discovered, unusual metabolic transformations.
色氨酸是20种常见蛋白质ogenic氨基酸中化学结构最复杂且含量最少的一种，它是大量复杂微生物天然产物的生物合成前体。这些分子中的许多都是药物发现和开发的有前景的支架。色氨酸的化学特性，包括其结构中几乎每个原子都能进行酶促修饰的能力以及其发生自发的、非酶催化化学反应的倾向，使其成为产生化学复杂性的独特生物前体。在这里，我们综述了使细菌能够将色氨酸掺入复杂代谢物的途径，重点关注最近发现的不寻常代谢转化。
