Papoudou-Bai Alexandra, Barbouti Alexandra, Galani Vassiliki, Stefanaki Kalliopi, Rontogianni Dimitra, Kanavaros Panagiotis
Department of Pathology, University of Ioannina, Ioannina, Greece.
Department of Anatomy-Histology-Embryology, University of Ioannina, Ioannina, Greece.
Clin Exp Med. 2016 May;16(2):147-59. doi: 10.1007/s10238-015-0344-7. Epub 2015 Mar 21.
The human thymus supports the production of self-tolerant T cells with competent and regulatory functions. Various cellular components of the thymic microenvironment such as thymic epithelial cells (TEC) and dendritic cells play essential roles in thymic T cell differentiation. The multiple cellular events occurring during thymic T cell and TEC differentiation involve proteins regulating cell cycle and apoptosis. Dysregulation of the cell cycle and apoptosis networks is involved in the pathogenesis of thymic epithelial tumors (TET) which are divided into two broad categories, thymomas and thymic carcinomas. The present review focuses on the usefulness of the analysis of the expression patterns of major cell cycle and apoptosis regulators in order to gain insight in the histophysiology of thymus and the histopathology, the clinical behavior and the biology of TET.
人类胸腺支持具有功能活性和调节功能的自身耐受T细胞的产生。胸腺微环境的各种细胞成分，如胸腺上皮细胞（TEC）和树突状细胞，在胸腺T细胞分化中起重要作用。胸腺T细胞和TEC分化过程中发生的多种细胞事件涉及调节细胞周期和凋亡的蛋白质。细胞周期和凋亡网络的失调与胸腺上皮肿瘤（TET）的发病机制有关，TET分为两大类，即胸腺瘤和胸腺癌。本综述重点关注分析主要细胞周期和凋亡调节因子的表达模式的实用性，以便深入了解胸腺的组织生理学以及TET的组织病理学、临床行为和生物学特性。
