Fischer A M, Dautzenberg M D, Aurousseau M H, Béguin S, Goudemand J, Hemker H C
Thromb Res. 1985 Jan 15;37(2):295-307. doi: 10.1016/0049-3848(85)90018-0.
Pentosan polysulphate is an heparin analogue which acts via an antithrombin III (AT III) independent pathway. We compared the effect of this drug to that of heparin and AT III infusions in AT III deficient patients. Four patients with AT III congenital deficiency received on three different occasions: (i) an infusion of human AT III concentrate (20 U/kg or 40 U/kg), (ii) an intramuscular injection of pentosan polysulphate (2 mg/kg), (iii) a subcutaneous calcium heparin injection (100 U/kg). AT III infusion inhibits the excessive thrombin generation (46% of inhibition) observed in the plasma of AT III deficient patients during at least 12 hours, but does not modify the factor Xa formation. On the contrary, pentosan polysulphate has a marked effect on both thrombin (62% of inhibition) and factor Xa generation (57% of inhibition) still present 8 hours after injection. Heparin injection has the same effect, more prolonged, as pentosan polysulphate on thrombin generation but is not so effective on impairing factor Xa generation (27% of inhibition). The marked effect of pentosan polysulphate on thrombin and factor Xa generation in these patients is due to its AT III independent mechanism of action.
戊聚糖多硫酸盐是一种肝素类似物，其作用途径不依赖抗凝血酶III（AT III）。我们比较了该药物与肝素和AT III输注对AT III缺乏患者的影响。4例先天性AT III缺乏患者在三种不同情况下接受治疗：（i）输注人AT III浓缩物（20 U/kg或40 U/kg），（ii）肌肉注射戊聚糖多硫酸盐（2 mg/kg），（iii）皮下注射钙肝素（100 U/kg）。AT III输注可抑制AT III缺乏患者血浆中观察到的过度凝血酶生成（抑制率46%），至少持续12小时，但不改变Xa因子的形成。相反，戊聚糖多硫酸盐对凝血酶（抑制率62%）和Xa因子生成（抑制率57%）均有显著作用，注射后8小时仍存在。肝素注射对凝血酶生成的作用与戊聚糖多硫酸盐相同，但持续时间更长，对Xa因子生成的抑制作用不如戊聚糖多硫酸盐有效（抑制率27%）。戊聚糖多硫酸盐对这些患者凝血酶和Xa因子生成的显著作用归因于其不依赖AT III的作用机制。
