Cinar Muhammet, Yilmaz Sedat, Cinar Fatma Ilknur, Koca Suleyman Serdar, Erdem Hakan, Pay Salih, Dinc Ayhan, Yazici Yusuf, Simsek Ismail
Division of Rheumatology, School of Medicine, Gulhane Military Medical Academy, Gn.Tevfik Sağlam Cad., 06018, Etlik, Ankara, Turkey,
Rheumatol Int. 2015 Sep;35(9):1575-80. doi: 10.1007/s00296-015-3256-7. Epub 2015 Mar 21.
A single questionnaire regarding to disease activity for all rheumatic diseases may present advantages to introduce quantitative measurement into routine care. The aim of this study was to evaluate the correlation of routine assessment of patient index data 3 (RAPID3) with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS). A total of 341 consecutive AS patients who met the modified New York classification criteria were included. All patients completed BASDAI and RAPID3 at each visit, and their physicians completed physician global assessment. ASDASs were calculated using defined formulas. Proposed RAPID3 severity categories were compared to BASDAI and ASDAS categories. Spearman's rho correlation test and kappa statistics were used to analyze statistical significance. The median age of AS patients was 34.0 (21.0-69.0) years and the median disease duration 10.0 (2.0-35.0) years. Median scores for RAPID3, BASDAI, ASDAS-CRP, and ASDAS-ESR were 13.0 (0.0-27.3), 4.7 (0.0-9.7), 3.0 (0.4-5.8), and 2.5 (0.5-6.3), respectively. RAPID3 was strongly correlated with BASDAI and ASDAS-ESR (r = 0.842, r = 0.815; p < 0.001, respectively). Among the 209 patients with high disease activity according to BASDAI, 83.3 % had high or moderate severity according to RAPID3 (kappa 0.693; p < 0.001). Among the 133 patients with moderate, high, and very high disease activity on ASDAS-CRP, 91.7 % had high or moderate severity according to RAPID3 (kappa 0.548; p < 0.001). RAPID3 is as informative as BASDAI and ASDAS in our cohort of AS patients. We therefore suggest that RAPID3 may be used to assess the patient status quantitatively in AS patients, as part of routine care.
一份针对所有风湿性疾病的疾病活动度调查问卷，可能有助于将定量测量引入常规护理。本研究旨在评估患者指数数据3（RAPID3）的常规评估与巴斯强直性脊柱炎疾病活动指数（BASDAI）和强直性脊柱炎疾病活动评分（ASDAS）之间的相关性。共纳入341例符合改良纽约分类标准的连续强直性脊柱炎患者。所有患者每次就诊时均完成BASDAI和RAPID3评估，其医生完成医生整体评估。使用既定公式计算ASDAS。将提议的RAPID3严重程度类别与BASDAI和ASDAS类别进行比较。采用Spearman秩相关检验和kappa统计分析统计学意义。强直性脊柱炎患者的中位年龄为34.0（21.0 - 69.0）岁，中位病程为10.0（2.0 - 35.0）年。RAPID3、BASDAI、ASDAS - CRP和ASDAS - ESR的中位评分分别为13.0（0.0 - 27.3）、4.7（0.0 - 9.7）、3.0（0.4 - 5.8）和2.5（0.5 - 6.3）。RAPID3与BASDAI和ASDAS - ESR密切相关（r分别为0.842和0.815；p均<0.001）。在根据BASDAI判断为疾病活动度高的209例患者中，83.3%根据RAPID3判断为高或中度严重程度（kappa为0.693；p<0.001）。在ASDAS - CRP评估为中度、高度和非常高疾病活动度的133例患者中，91.7%根据RAPID3判断为高或中度严重程度（kappa为0.548；p<0.001）。在我们的强直性脊柱炎患者队列中，RAPID3与BASDAI和ASDAS的信息量相当。因此，我们建议RAPID3可作为常规护理的一部分，用于定量评估强直性脊柱炎患者的病情。
