Goel S K, Lalwani N D, Fahl W E, Reddy J K
Toxicol Lett. 1985 Jan;24(1):37-43. doi: 10.1016/0378-4274(85)90137-7.
[3H][2-methyl-2-p-(1,2,3,4-tetrahydro-naphthyl)phenoxy] propionic acid (nafenopin), a hepatocarcinogenic peroxisome proliferator, when administered p.o. to normal intact and partially hepatectomized male F344 rats did not show any significant binding to DNA and RNA, but bound to proteins. The in vitro incubation of [3H]nafenopin and [3H]4-chloro-[6-(2,3-xylidino)pyrimidinylthio]acetic acid (Wy-14643), another peroxisome proliferator, with hepatic microsomes and calf thymus DNA also showed no significant binding of these chemicals to DNA.
[3H][2-甲基-2-p-(1,2,3,4-四氢萘基)苯氧基]丙酸（萘酚平）是一种具有致癌性的过氧化物酶体增殖剂，经口给予正常完整和部分肝切除的雄性F344大鼠时，它与DNA和RNA无明显结合，但能与蛋白质结合。[3H]萘酚平和[3H]4-氯-[6-(2,3-二甲基苯胺基)嘧啶基硫代]乙酸（Wy-14643）（另一种过氧化物酶体增殖剂）与肝微粒体及小牛胸腺DNA进行体外温育时，这些化学物质与DNA也无明显结合。
