嘧啶并嘧啶类化合物的化学和生物学研究进展。
Recent advances in the chemistry and biology of pyridopyrimidines.
机构信息
Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, rue de Chartres, BP 6759, 45067 Orléans Cedex 2, France.
Équipe de Chimie Bioorganique & Analytique, URAC 22, Université Hassan II Mohammedia-Casablanca, BP 146, 28800 Mohammedia, Morocco.
出版信息
Eur J Med Chem. 2015 May 5;95:76-95. doi: 10.1016/j.ejmech.2015.03.029. Epub 2015 Mar 14.
The interest in pyridopyrimidine cores for pharmaceutical products makes this scaffold a highly useful building block for organic chemistry. These derivatives have found applications in various areas of medicine such as anticancer, CNS, fungicidal, antiviral, anti-inflammatory, antimicrobial, and antibacterial therapies. This review mainly focuses on the progress achieved since 2004 in the chemistry and biological activity of pyridopyrimidines.
对用于药物产品的吡啶并嘧啶核心的兴趣使该支架成为有机化学中非常有用的构建块。这些衍生物已在医学的各个领域得到应用，如抗癌、中枢神经系统、杀真菌、抗病毒、抗炎、抗菌和抗细菌疗法。本篇综述主要关注自 2004 年以来在吡啶并嘧啶化学和生物活性方面取得的进展。
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