Meta-analysis of Foley catheter plus misoprostol versus misoprostol alone for cervical ripening.

BACKGROUND

The effectiveness of Foley catheter plus misoprostol for cervical ripening has not been convincingly shown in trials.

OBJECTIVES

To summarize the evidence comparing Foley catheter plus misoprostol versus misoprostol alone for cervical ripening.

SEARCH STRATEGY

Embase, Medline, and Cochrane Collaboration databases were searched with the terms "Foley catheter," "misoprostol," "cervical ripening," and "labor induction."

SELECTION CRITERIA

Randomized controlled trials comparing the methods of cervical ripening for delivery of a viable fetus were included.

DATA COLLECTION AND ANALYSIS

Study characteristics, quality, and outcomes were recorded. Random-effects models were used to combine data.

MAIN RESULTS

Eight trials were included, with 1153 patients overall. In a pooled analysis of seven high-quality studies, the combination group had a decreased time to delivery (mean difference -2.36 hours, 95% confidence interval [CI] -4.07 to -0.66; P=0.007). Risk of chorioamnionitis was significantly increased in the combination group (risk ratio [RR] 2.07, 95% CI 1.04-4.13; P=0.04), and that of tachysystole with fetal heart rate changes was decreased (RR 0.58, 95% CI 0.38-0.91; P=0.02). Frequency of cesarean did not differ (P=0.77).

CONCLUSIONS

The combined use of Foley catheter and misoprostol results in a reduced time to delivery, a reduced frequency tachysystole with fetal heart rate changes, and an increased incidence of chorioamnionitis.