脂肪酶：用于动态动力学拆分的有价值的催化剂。
Lipases: Valuable catalysts for dynamic kinetic resolutions.
机构信息
Laboratory of Biocatalysis and Organic Synthesis, Universidade Federal do Rio de Janeiro, Instituto de Química, Cidade Universitária, Rio de Janeiro CEP21941909, Brazil.
Laboratory of Biocatalysis and Organic Synthesis, Universidade Federal do Rio de Janeiro, Instituto de Química, Cidade Universitária, Rio de Janeiro CEP21941909, Brazil.
出版信息
Biotechnol Adv. 2015 Sep-Oct;33(5):372-93. doi: 10.1016/j.biotechadv.2015.02.015. Epub 2015 Mar 17.
Dynamic kinetic resolutions have proven to be a useful method for the preparation of enantiopure compounds from racemates, leading to the formation of a single enantiomer in theoretically 100% yield. Because lipases are ubiquitous, versatile, stereoselective and robust biocatalysts, they have been successfully applied as co-catalysts in these reactions, being mostly combined with metals in the chemoenzymatic dynamic kinetic resolutions of alcohols and amines.
动态动力学拆分已被证明是一种从外消旋体中制备对映纯化合物的有用方法，可使单一对映异构体在理论上以 100%的产率形成。由于脂肪酶是无处不在的、多功能的、立体选择性的和稳健的生物催化剂，它们已成功地作为共催化剂应用于这些反应中，主要与金属一起用于醇和胺的化学酶动态动力学拆分。
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