The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, UK.
The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, UK.
Trends Plant Sci. 2015 May;20(5):269-272. doi: 10.1016/j.tplants.2015.02.005. Epub 2015 Mar 18.
Tyrosine phosphorylation is an important post-translational modification that is known to regulate receptor kinase (RK)-mediated signaling in animals. Plant RKs are annotated as serine/threonine kinases, but recent work has revealed that tyrosine phosphorylation is also crucial for the activation of RK-mediated signaling in plants. These initial observations have paved the way for subsequent detailed studies on the mechanism of activation of plant RKs and the biological relevance of tyrosine phosphorylation for plant growth and immunity. In this Opinion article we review recent reports on the contribution of RK tyrosine phosphorylation in plant growth and immunity; we propose that tyrosine phosphorylation plays a major regulatory role in the initiation and transduction of RK-mediated signaling in plants.
酪氨酸磷酸化是一种重要的翻译后修饰，已知其可调节动物中的受体激酶（RK）介导的信号转导。植物 RK 被注释为丝氨酸/苏氨酸激酶，但最近的研究表明，酪氨酸磷酸化对于植物 RK 介导的信号转导的激活也至关重要。这些初步观察为随后对植物 RK 的激活机制以及酪氨酸磷酸化对植物生长和免疫的生物学相关性的详细研究铺平了道路。在本观点文章中，我们回顾了最近关于 RK 酪氨酸磷酸化在植物生长和免疫中的作用的报告；我们提出，酪氨酸磷酸化在植物中 RK 介导的信号转导的起始和转导中起主要的调节作用。
