Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations.
作者信息
Greber Boris, Verkerk Arie O, Seebohm Guiscard, Mummery Christine L, Bellin Milena
机构信息
Human Stem Cell Pluripotency Laboratory, Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany; Chemical Genomics Centre of the Max Planck Society, 44227 Dortmund, Germany;
Department of Anatomy, Embryology, and Physiology, Heart Failure Research Center, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands;
出版信息
Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1969. doi: 10.1073/pnas.1503762112. Epub 2015 Mar 20.
Abstract
摘要
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本文引用的文献
1
LQT1-phenotypes in hiPSC: Are we measuring the right thing?人诱导多能干细胞中的LQT1表型：我们测量的是正确的东西吗？
Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1968. doi: 10.1073/pnas.1503347112. Epub 2015 Mar 20.
2
Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue.耶尔韦尔和朗格-尼尔森综合征诱导多能干细胞模型中的隐性心脏表型：疾病机制与药物挽救
Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5383-92. doi: 10.1073/pnas.1419553111. Epub 2014 Dec 1.
3
Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry.人胚胎干细胞来源的心肌细胞中慢钾通道的生物物理特性表明亚基组成比例。
J Physiol. 2011 Dec 15;589(Pt 24):6093-104. doi: 10.1113/jphysiol.2011.220863. Epub 2011 Oct 24.
4
Patient-specific induced pluripotent stem-cell models for long-QT syndrome.长 QT 综合征的患者特异性诱导多能干细胞模型。
N Engl J Med. 2010 Oct 7;363(15):1397-409. doi: 10.1056/NEJMoa0908679. Epub 2010 Jul 21.
5
Blockade of the I(Ks) potassium channel: an overlooked cardiovascular liability in drug safety screening?I(Ks) 钾通道阻滞：药物安全性筛查中被忽视的心血管风险？
J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):1-10. doi: 10.1016/j.vascn.2009.04.197. Epub 2009 May 9.
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