Sebaratnam Deshan F, Okawa Joyce, Payne Aimee, Murrell Dédée F, Werth Victoria P
Department of Dermatology, University of New South Wales, St George Hospital Campus, Sydney, Australia.
Qual Life Res. 2015 Sep;24(9):2257-60. doi: 10.1007/s11136-015-0965-z. Epub 2015 Mar 21.
To evaluate the reliability of the autoimmune bullous diseases quality of life (ABQOL) questionnaire in a North American patient cohort.
Patients attending the dermatology clinics of the University of Pennsylvania with a histological diagnosis of an autoimmune bullous disease (AIBD) and self-reported proficiency in English were recruited to participate in the study. Patients completed the ABQOL questionnaire at Day 0 and Day 3. Internal consistency was calculated through Cronbach's alpha. Test-retest reliability was determined by the intraclass correlation coefficient.
Of the 45 patients enrolled in the study, 39 patients (87 %) participated to completion. The mean age was 60.7 years with an equal sex distribution observed. Patients had a range of AIBD including pemphigus vulgaris, bullous pemphigoid, pemphigus foliaceus, epidermolysis bullosa acquisita, mucous membrane pemphigoid and linear IgA disease. Cronbach's alpha was calculated to be 0.90. The intraclass correlation coefficient was calculated to be 0.93 (95 % confidence interval 0.88-0.94).
The ABQOL was found to be reliable tested by internal consistency and test-retest reliability in an American patient cohort. It represents a promising disease-specific outcome measure for patients with AIBD.
评估自身免疫性大疱性疾病生活质量（ABQOL）问卷在北美患者队列中的可靠性。
招募宾夕法尼亚大学皮肤科门诊经组织学诊断为自身免疫性大疱性疾病（AIBD）且自我报告英语熟练的患者参与研究。患者在第0天和第3天完成ABQOL问卷。通过Cronbach's α计算内部一致性。通过组内相关系数确定重测信度。
在纳入研究的45例患者中，39例（87%）完成了研究。平均年龄为60.7岁，性别分布均衡。患者患有多种AIBD，包括寻常型天疱疮、大疱性类天疱疮、落叶型天疱疮、获得性大疱性表皮松解症、黏膜类天疱疮和线状IgA疾病。计算得出Cronbach's α为0.90。组内相关系数计算得出为0.93（95%置信区间0.88 - 0.94）。
在美国患者队列中，通过内部一致性和重测信度测试发现ABQOL是可靠的。它是一种有前景的针对AIBD患者的疾病特异性结局指标。
