Witt Suzanne T, Stevens Michael C
Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, 200 Retreat Avenue, ONRC, Whitehall Building, Hartford, CT 06106, USA; Center for Medical Imaging and Visualization (CMIV), Linköping University, SE-581 85 Linköping, Sweden.
Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, 200 Retreat Avenue, ONRC, Whitehall Building, Hartford, CT 06106, USA; Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA.
Psychiatry Res. 2015 May 30;232(2):168-74. doi: 10.1016/j.pscychresns.2015.02.009. Epub 2015 Mar 5.
The present study sought to evaluate whether white matter microstructure abnormalities observed in a cohort of adolescents with attention-deficit/hyperactivity disorder (ADHD) have specific relationships with either or both Hyperactivity/Impulsivity and Inattentive ADHD symptom domains that would support a dimensional view of ADHD as adopted in the DSM-V. Diffusion tensor imaging (DTI) data were acquired on 22 adolescents diagnosed with ADHD. Multiple regression analyses were performed to determine whether scalar DTI measures in 13 tracts-of-interest demonstrated meaningful associations with Hyperactivity/Impulsivity or Inattentive symptom severity. Fractional anisotropy and radial diffusivity measures of white matter integrity exhibited significant linear relationships with Hyperactivity/Impulsivity and Inattentive symptom severity. However, only radial diffusivity in the right superior longitudinal fasciculus was specifically linked to Inattentive symptom severity and not Hyperactivity/Impulsivity symptom severity. Our results provide preliminary evidence that symptom domains in ADHD are linked to neuroanatomical substrates and confirm the value in examining ADHD from a dimensional perspective.
本研究旨在评估在一组患有注意力缺陷多动障碍（ADHD）的青少年中观察到的白质微观结构异常是否与多动/冲动及注意力不集中这两个ADHD症状领域中的一个或两个存在特定关系，这将支持《精神疾病诊断与统计手册》第五版（DSM-V）中采用的ADHD维度观。对22名被诊断为ADHD的青少年进行了扩散张量成像（DTI）数据采集。进行了多元回归分析，以确定13个感兴趣区域的标量DTI测量值是否与多动/冲动或注意力不集中症状严重程度存在有意义的关联。白质完整性的分数各向异性和径向扩散率测量值与多动/冲动及注意力不集中症状严重程度呈现出显著的线性关系。然而，只有右侧上纵束的径向扩散率与注意力不集中症状严重程度有特定关联，而与多动/冲动症状严重程度无关。我们的结果提供了初步证据，表明ADHD中的症状领域与神经解剖学基质有关，并证实了从维度角度研究ADHD的价值。
