Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China; Cyber Innovation Joint Research Center, Zhejiang University, Hangzhou 310027, PR China.
Micro and Nanotechnology Lab, University of Illinois at Urbana-Champaign, Illinois 61801, USA.
Biosens Bioelectron. 2015 Aug 15;70:81-8. doi: 10.1016/j.bios.2015.03.004. Epub 2015 Mar 11.
Rapid, sensitive, selective and portable detection of 2,4,6-trinitrotoluene (TNT) is in high demand for public safety and environmental monitoring. In this study, we reported a smartphone-based system using impedance monitoring for TNT detection. The screen-printed electrodes modified with TNT-specific peptides were used as disposable a biosensor to produce impedance responses to TNT. The responses could be monitored by a hand-held device and send out to smartphone through Bluetooth. Then, the smartphone was used to display TNT responses in real time and report concentration finally. In the measurement, the system was demonstrated to detect TNT at concentration as low as 10(-6) M and distinguish TNT versus different chemicals in high specificity. Thus, the smartphone-based biosensing platform provided a convenient and efficient approach to design portable instruments for chemical detections such as TNT recognition.
快速、灵敏、选择性和便携的 2,4,6-三硝基甲苯（TNT）检测对于公共安全和环境监测至关重要。在本研究中，我们报告了一种基于智能手机的系统，该系统使用阻抗监测进行 TNT 检测。经过 TNT 特异性肽修饰的丝网印刷电极被用作一次性生物传感器，可对 TNT 产生阻抗响应。通过蓝牙，可将响应由手持设备进行监测并传输到智能手机。然后，智能手机用于实时显示 TNT 响应，并最终报告浓度。在测量中，该系统被证明能够以低至 10(-6) M 的浓度检测 TNT，并具有高特异性地区分 TNT 与不同化学物质。因此，基于智能手机的生物传感平台为设计便携式仪器以进行 TNT 识别等化学检测提供了一种便捷、高效的方法。
