Shan Yangyang, Li Shenglei
The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Pak J Pharm Sci. 2015 Mar;28(2 Suppl):739-43.
To research the expression in human lung adenocarcinoma tissue of Cripto-1 (teratocarcinoma derived growth factor-1) gene protein and Activin-A gene protein, and explore the relationship and clinical significance between the two gene protein and clinical pathological characteristic of lung adenocarcinoma. This study had applied the immunohistochemical method to detect the 188 cases of lung adenocarcinoma and expression of Cripto-1 protein and Activin-A protein in 100 cases of normal lung tissue. Then, analysis the relationship between these two-gene protein and clinical lung adenocarcinoma histopathological features, and inherent correlation between these two genes. The positive expression rate of Cripto-1 protein in lung adenocarcinoma tissue was significantly higher in normal lung tissue, while, the positive expression rate of Activin-A protein in lung adenocarcinoma tissue was significantly lower than in normal lung tissue. The high expression of Cripto-1 and low expression of Activin-A was closely related (each P<0.05) to the TNM staging of lung adenocarcinoma, lymph node metastasis and the main pathological tissue staging of lung adenocarcinoma. And the correlation analysis showed that it was negative correlation for the expression of Activin-A protein and Cripto-1 protein in lung adenocarcinoma. The over expression of Cripto-1 and the expression lack of Activin-A were correlated with the occurrence, development, metastasis and malignant degree of lung adenocarcinoma.
研究Cripto-1（畸胎瘤衍生生长因子-1）基因蛋白和激活素A基因蛋白在人肺腺癌组织中的表达，探讨这两种基因蛋白与肺腺癌临床病理特征之间的关系及临床意义。本研究应用免疫组织化学方法检测188例肺腺癌组织及100例正常肺组织中Cripto-1蛋白和激活素A蛋白的表达。然后，分析这两种基因蛋白与肺腺癌临床组织病理学特征之间的关系，以及这两种基因之间的内在相关性。肺腺癌组织中Cripto-1蛋白的阳性表达率显著高于正常肺组织，而肺腺癌组织中激活素A蛋白的阳性表达率显著低于正常肺组织。Cripto-1的高表达和激活素A的低表达与肺腺癌的TNM分期、淋巴结转移及肺腺癌主要病理组织分期密切相关（各P<0.05）。相关性分析显示，肺腺癌中激活素A蛋白与Cripto-1蛋白的表达呈负相关。Cripto-1的过表达和激活素A的表达缺失与肺腺癌的发生、发展、转移及恶性程度相关。
