Wang Pu, Luo Cheng, Dong Li, Bin Yi, Ma Shi, Yao Dezhong, Guo Fuqiang, Yang Zhenglin
College of Material Sciences and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, China; Department of Neurology, Chongzhou People's Hospital, Chongzhou, Sichuan, China; Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China; Department of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
J Neurol Sci. 2015 Apr 15;351(1-2):133-139. doi: 10.1016/j.jns.2015.03.005. Epub 2015 Mar 10.
To investigate localized cerebral function abnormalities in patients with familial cortical myoclonic tremor and epilepsy (FCMTE) using resting-state functional magnetic resonance imaging (fMRI).
Seven patients with FCMTE from a Chinese family, seven patients with essential tremor (ET), and ten healthy controls were recruited. Amplitude of low-frequency fluctuation (ALFF) analysis was utilized to reveal the potential functional changes in patients with FCMTE.
Significant differences in the bilateral frontal lobe and fusiform gyrus among the three groups were revealed by one-way analysis of variance (ANOVA). The t-tests between groups were performed to compare ALFF in these ROIs. The FCMTE subjects exhibited decreased ALFF in the right fusiform gyrus and posterior cingulate cortex (PCC) with increased ALFF in the frontal lobe, compared with the ET and healthy control groups. Furthermore, the ALFF in the frontal lobe was positively correlated with the duration of tremor in patients with FCMTE and ET.
These findings suggest that frontal cortex and PCC impairment might be related to the epileptic activity and that the abnormality of the fusiform gyrus may be associated with impairment of visuospatial in FCMTE. Due to the positive correlation between the duration of tremor and ALFF in the frontal lobe, changes in the frontal lobe could be a potential indicator of a candidate causative gene for FCMTE.
使用静息态功能磁共振成像（fMRI）研究家族性皮质肌阵挛性震颤伴癫痫（FCMTE）患者的局部脑功能异常。
招募了来自一个中国家庭的7例FCMTE患者、7例特发性震颤（ET）患者和10名健康对照者。采用低频振幅（ALFF）分析来揭示FCMTE患者潜在的功能变化。
通过单因素方差分析（ANOVA）揭示了三组之间双侧额叶和梭状回存在显著差异。进行组间t检验以比较这些感兴趣区域（ROIs）中的ALFF。与ET组和健康对照组相比，FCMTE受试者右侧梭状回和后扣带回皮质（PCC）的ALFF降低，而额叶的ALFF升高。此外，FCMTE和ET患者额叶的ALFF与震颤持续时间呈正相关。
这些发现表明额叶皮质和PCC损伤可能与癫痫活动有关，并且梭状回异常可能与FCMTE中的视觉空间损害有关。由于额叶震颤持续时间与ALFF之间存在正相关，额叶的变化可能是FCMTE候选致病基因的潜在指标。
