Thilagam Alagu
Mawson Institute, Information Technology, Engineering and Environment, University of South Australia, Adelaide 5095, South Australia.
Math Med Biol. 2016 Mar;33(1):107-21. doi: 10.1093/imammb/dqv006. Epub 2015 Mar 21.
The factors which govern the subtle links between follicle loss and mammalian female reproductive ageing remain unclear despite extensive studies undertaken to understand the critical physiological and biochemical mechanisms that underly the accelerated decline in follicle numbers in women older than 37 years. It is not certain whether there is a sole control by the ovary or whether other factors which affect ageing also intersect with the ovarian effect. There is convincing experimental evidence for an interplay of several processes that seem to influence the follicle loss-female reproductive ageing links, with specific hormones (follicle-stimulating hormone, anti-Müllerian hormone, dehydroepiandrosterone) noted to play important roles in follicular dynamics and ovarian ageing. In this work, we examine the subtle links between the rate of follicular decline with ageing and the role of hormones via a series of non-autonomous equations. Simulation results based on the time evolution of the number of ovarian follicles and biochemical changes in the ovarian environment influenced by hormone levels is compared with empirical data based on follicle loss-reproductive ageing correlation studies.
尽管已经进行了广泛的研究，以了解37岁以上女性卵泡数量加速下降背后的关键生理和生化机制，但控制卵泡丢失与哺乳动物雌性生殖衰老之间微妙联系的因素仍不清楚。目前尚不确定这是否仅受卵巢控制，或者影响衰老的其他因素是否也与卵巢效应相互作用。有令人信服的实验证据表明，几个过程之间存在相互作用，似乎影响着卵泡丢失与雌性生殖衰老之间的联系，其中特定激素（促卵泡激素、抗苗勒管激素、脱氢表雄酮）在卵泡动态和卵巢衰老中起着重要作用。在这项工作中，我们通过一系列非自治方程研究卵泡随年龄下降的速率与激素作用之间的微妙联系。将基于卵巢卵泡数量的时间演变以及受激素水平影响的卵巢环境生化变化的模拟结果，与基于卵泡丢失与生殖衰老相关性研究的实证数据进行比较。
