2-(2-氨基乙基)-氨基甲基-吡啶-6-羧基组氨酸甲酯（AMPHIS）的铜（II）和铁（II）配合物，一种模拟博来霉素金属螯合部分的肽。电子自旋共振研究。

Copper(II)- and iron(II)-complexes of methyl 2-(2-aminoethyl)-aminomethyl-pyridine-6-carboxyl-histidinate (AMPHIS), a peptide mimicking the metal-chelating moiety of bleomycin. An ESR investigation.

作者信息

Hénichart J P, Bernier J L, Houssin R, Lohez M, Kenani A, Catteau J P

出版信息

Biochem Biophys Res Commun. 1985 Feb 15;126(3):1036-41. doi: 10.1016/0006-291x(85)90289-x.

Abstract

Methyl 2-(2-aminoethyl)-aminomethyl-pyridine-6-carboxyl-histidinate (AMPHIS), a synthetic analogue of the chelating part of bleomycin (BLM), has been studied for its metal binding properties. Electron spin resonance parameters of AMPHIS-Cu(II) and BLM-Cu(II) have been found to be closely similar likewise spectra of oxygen radicals spin-adducts induced by AMPHIS-Fe(II)-O2 and BLM-Fe(II)-O2 systems. Thus, AMPHIS could constitute a very useful tool for the study of BLM mode of action.

摘要

2-(2-氨基乙基)-氨基甲基-吡啶-6-羧基组氨酸甲酯（AMPHIS）是博来霉素（BLM）螯合部分的合成类似物，已对其金属结合特性进行了研究。已发现AMPHIS-Cu(II)和BLM-Cu(II)的电子自旋共振参数非常相似，同样，AMPHIS-Fe(II)-O2和BLM-Fe(II)-O2体系诱导的氧自由基自旋加合物的光谱也很相似。因此，AMPHIS可能成为研究BLM作用模式的非常有用的工具。