哺乳动物速激肽诱导大鼠脑片肌醇磷脂的水解。
Mammalian tachykinin-induced hydrolysis of inositol phospholipids in rat brain slices.
作者信息
Hunter J C, Goedert M, Pinnock R D
出版信息
Biochem Biophys Res Commun. 1985 Mar 15;127(2):616-22. doi: 10.1016/s0006-291x(85)80205-9.
PMID:2579657
Abstract
The mammalian tachykinins substance K, neuromedin K and substance P stimulated inositol phospholipid hydrolysis in paired coronal sections through the rat brain. In contrast, none of these peptides had any effect on either basal or forskolin-stimulated cyclic AMP levels. The present results therefore implicate inositol phospholipid hydrolysis as a possible second messenger system mediating the effects of substance K and neuromedin K in addition to substance P.
摘要
哺乳动物速激肽物质K、神经介素K和P物质可刺激大鼠脑成对冠状切片中的肌醇磷脂水解。相比之下，这些肽对基础或福斯高林刺激的环磷酸腺苷水平均无任何影响。因此，目前的结果表明，除P物质外，肌醇磷脂水解可能是介导物质K和神经介素K作用的第二信使系统。
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