Devillier P, Regoli D, Asseraf A, Descours B, Marsac J, Renoux M
Pharmacology. 1986;32(6):340-7. doi: 10.1159/000138190.
Substance P and two recently identified neurokinins, substance K and neuromedin K as well as the nonmammalian tachykinin kassinin were compared for histamine-releasing abilities from rat mast cells, plasma extravasation effects on rat skin, and wheal and flare responses on human skin. Among the four tachykinins, a significantly dose-dependent histamine release from rat mast cells and a flare response in human skin was observed only with substance P, indicating the possible implication of histamine in this response. On the other hand, the four peptides were similarly active on the wheal response (plasma extravasation produced by increased permeability of capillaries and venules) in human skin and on the plasma extravasation in the rat skin, suggesting a dissociation of effects and possibly of receptors.
对P物质、两种最近鉴定出的神经激肽（物质K和神经介素K）以及非哺乳动物速激肽蟾蜍速激肽进行了比较，观察它们从大鼠肥大细胞释放组胺的能力、对大鼠皮肤的血浆外渗作用以及对人体皮肤的风团和潮红反应。在这四种速激肽中，仅观察到P物质能使大鼠肥大细胞显著剂量依赖性地释放组胺，并引起人体皮肤潮红反应，这表明组胺可能参与了该反应。另一方面，这四种肽对人体皮肤的风团反应（由毛细血管和小静脉通透性增加导致的血浆外渗）以及大鼠皮肤的血浆外渗具有相似的活性，提示效应和可能的受体存在分离。
