Liu Ji-hong, Luan Yang
Zhonghua Nan Ke Xue. 2015 Feb;21(2):99-106.
Erectile dysfunction (ED), as a common male disease, seriously affects the patients' sexual life quality. Most ED patients benefit from phosphodiesterase type 5 (PDE5) inhibitors, but some refractory ED sufferers fail to respond to them. With the rapid development of molecular biology, the relevant molecular signaling pathways of penile erection and molecular pathogenesis of ED have been gradually clarified, and attempts have been made at a better management or a complete cure of ED with advanced molecular biological methods such as the gene therapy. This article presents an overview on the research progress in the molecular signaling pathways, molecular pathogenesis, and gene therapy of ED.
勃起功能障碍（ED）作为一种常见的男性疾病，严重影响患者的性生活质量。大多数ED患者受益于5型磷酸二酯酶（PDE5）抑制剂，但一些难治性ED患者对其无反应。随着分子生物学的快速发展，阴茎勃起的相关分子信号通路及ED的分子发病机制已逐渐明确，并且已经尝试采用基因治疗等先进的分子生物学方法对ED进行更好的管理或彻底治愈。本文综述了ED在分子信号通路、分子发病机制及基因治疗方面的研究进展。
