异喹啉是煤焦油中一种可能的抗银屑病药物。
Isoquinoline is a possible anti-psoriatic agent in coal tar.
作者信息
Foreman M I, Taylor M, Clark C, Devitt H, Hanlon G, Kelly I, Lukowiecki G
出版信息
Br J Dermatol. 1985 Mar;112(3):323-8. doi: 10.1111/j.1365-2133.1985.tb04860.x.
Abstract
Isoquinoline has been identified as a component of coal tar which causes interfollicular regions of parakeratotic stratum corneum in mouse tail epidermis to become orthokeratotic, with concomitant production of a granular layer. In this respect it behaves similarly to coal tar itself, and isoquinoline may contribute to the anti-psoriatic activity of coal tar.
摘要
异喹啉已被确定为煤焦油的一种成分，它可使小鼠尾部表皮角化不全角质层的毛囊间区域转变为正角化，并伴随颗粒层的产生。在这方面，它的作用与煤焦油本身相似，异喹啉可能有助于煤焦油的抗银屑病活性。
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