Schleich F, Louis R
Rev Med Liege. 2014;69 Spec No:62-5.
Asthma is a complex chronic inflammatory disease of the airways. Eosinophilia is a recognized feature of asthma. Asthma is no more considered as a single disease, but there are several subtypes of bronchial asthma, also called phenotypes, that have therapeutic and prognostic implications. Asthmatics are now classified according to inflammatory phenotypes that allow a personalized therapy. Phenotype identification requires induced sputum analysis that is not widely available. In this context, we have identified surrogate markers for inflammatory phenotypes. An eosinophilic phenotype can lbe suspected in case of concomitant increase of exhaled nitric oxide, blood eosinophils, IgE levels and airway obstruction. We have also identified a subgroup of asthmatics exhibiting diffuse local and systemic eosinophilia. This subgroup has a more severe asthma,a lower asthma control and a higher number of exacerbations.
哮喘是一种复杂的气道慢性炎症性疾病。嗜酸性粒细胞增多是哮喘的一个公认特征。哮喘不再被视为单一疾病，而是存在几种支气管哮喘亚型，也称为表型，它们具有治疗和预后意义。哮喘患者现在根据炎症表型进行分类，这有助于个性化治疗。表型识别需要诱导痰分析，但这种方法尚未广泛应用。在此背景下，我们已经确定了炎症表型的替代标志物。如果呼出一氧化氮、血液嗜酸性粒细胞、免疫球蛋白E水平同时升高且存在气道阻塞，则可能怀疑为嗜酸性粒细胞表型。我们还确定了一组表现出弥漫性局部和全身嗜酸性粒细胞增多的哮喘患者亚组。该亚组哮喘病情更严重，哮喘控制较差，急性加重次数更多。
