简单模型可以解释红细胞阴离子交换的自我抑制。
Simple model can explain self-inhibition of red cell anion exchange.
作者信息
Tanford C
出版信息
Biophys J. 1985 Jan;47(1):15-20. doi: 10.1016/S0006-3495(85)83871-6.
Abstract
Ion translocation in red cell anion exchange is assumed to occur by means of an alternating access mechanism, in which a critical binding site for the transported ion alternates between two conformational states, each accessible from only one side of the membrane. If this alternating site is located within the transport protein at some distance from one or both surfaces of the membrane, an access channel is required to connect the alternating site to the adjacent bulk solution. This automatically leads to inhibition of transport at high concentrations of the transported ion because release of the ion from the alternating site can occur only via unoccupied channel sites.
摘要
红细胞阴离子交换中的离子转运被认为是通过交替通路机制发生的，在该机制中，被转运离子的关键结合位点在两种构象状态之间交替，每种构象状态仅能从膜的一侧接近。如果这个交替位点位于转运蛋白内部，距膜的一个或两个表面有一定距离，那么就需要一个通道将交替位点与相邻的本体溶液相连。这必然会导致在被转运离子浓度较高时转运受到抑制，因为离子从交替位点的释放只能通过未被占据的通道位点进行。
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