Shibata Yo, Tanimoto Yasuhiro, Maruyama Noriko, Nagakura Manamu
Department of Conservative Dentistry, Division of Biomaterials & Engineering, Showa University School of Dentistry, Tokyo, Japan.
Department of Dental Biomaterials, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
J Prosthodont Res. 2015 Apr;59(2):84-95. doi: 10.1016/j.jpor.2015.01.003. Epub 2015 Mar 19.
The purpose of this article is to review the mechanical requirements of the tissue-implant interface and analyze related theories.
The osseointegration capacity of titanium implants has been investigated over the past 50 years. We considered the ultimate goal of osseointegration to which form a desirable interfacial layer and a bone matrix with adequate biomechanical properties.
Occasionally, the interface comprises porous titanium and bone ingrowth that enables a functionally graded Young's modulus, thereby allowing reduction of stress shielding. However, the optimal biomechanical connection at the interface has not yet been fully clarified. There have been publications supporting several universal mechanical testing technologies in terms of bone-titanium bonding ability, although the separation of newly formed bone quality is unlikely.
The understanding of complex mechanical bone behavior and size-dependent properties ranging from a nano- to a macroscopic level are essential in the biomechanical optimization of implants. The requirements of regenerated tissue at the interface include high strength, fracture toughness related to ductility, and time-dependent energy dissipation and/or elastic-plastic stress distribution. Moreover, a strong relationship between strain signals and peri-implant tissue turnover could be expected, so that ideal implant biomechanics may enable longevity via adaptive bone remodeling.
本文旨在回顾组织-植入物界面的力学要求并分析相关理论。
在过去50年中,人们对钛植入物的骨结合能力进行了研究。我们认为骨结合的最终目标是形成具有理想生物力学性能的界面层和骨基质。
偶尔,界面由多孔钛和骨长入组成,这使得杨氏模量能够功能分级,从而减少应力遮挡。然而,界面处的最佳生物力学连接尚未完全阐明。虽然不太可能区分新形成的骨质量,但已有文献支持几种关于骨-钛结合能力的通用力学测试技术。
在植入物的生物力学优化中,了解从纳米到宏观层面的复杂骨力学行为和尺寸依赖性特性至关重要。界面处再生组织的要求包括高强度、与延展性相关的断裂韧性以及随时间变化的能量耗散和/或弹塑性应力分布。此外,可以预期应变信号与种植体周围组织更新之间存在密切关系,因此理想的植入物生物力学可能通过适应性骨重塑实现长期使用。