通用的溴化铜催化的从末端炔醇制备光学活性联烯醇的高对映选择性方法。
General CuBr2-catalyzed highly enantioselective approach for optically active allenols from terminal alkynols.
作者信息
Huang Xin, Cao Tao, Han Yulin, Jiang Xingguo, Lin Weilong, Zhang Jiasheng, Ma Shengming
机构信息
Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, People's Republic of China.
出版信息
Chem Commun (Camb). 2015 Apr 25;51(32):6956-9. doi: 10.1039/c5cc00697j. Epub 2015 Mar 23.
PMID:25797036
Abstract
Here, we show a CuBr2-catalyzed approach for a highly enantioselective synthesis (93-99% ee) of allenols from aldehydes and terminal alkynols with the absolute configuration being controlled by applying readily available (R)- or (S)-α,α-diphenylprolinol.
摘要
在此，我们展示了一种由溴化铜催化的方法，用于从醛类和末端炔醇高效对映选择性合成联烯醇（对映体过量率为93 - 99%），其绝对构型可通过使用易于获得的（R）-或（S）-α，α-二苯基脯氨醇来控制。
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