Evidence for the existence of substance P-like immunoreactive neurons in the human cerebral cortex: an immunohistochemical analysis.

Cellular localization of substance P-like immunoreactive (SP-IR) structures in the pre- and postcentral gyri of the human cerebral cortex was examined by indirect immunofluorescence. SP-IR was localized mostly in bipolar and partly in multipolar cells in layers II and IV. SP-IR fibers were also noted in these gyri, especially in layers II and IV.