Department of Cardiology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
Department of Cardiology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
Can J Diabetes. 2015 Aug;39(4):317-21. doi: 10.1016/j.jcjd.2015.01.004. Epub 2015 Mar 19.
Emerging evidence suggests that the neutrophil-to-lymphocyte ratio (NLR) may be a useful marker of inflammation and aortic stiffness. Markers of inflammation and aortic stiffness are both indicators of cardiovascular events. We, therefore, investigated whether the NLR is associated with aortic stiffness in patients with type 1 diabetes mellitus.
We examined the relationship of the NLR to aortic stiffness in 76 people with type 1 diabetes and 36 healthy controls.
The NLRs in the group with type 1 diabetes were higher than in the controls (2.33±0.95 vs. 1.80±0.68, respectively; p=0.003). Aortic strain and aortic distensibility, the parameters of aortic stiffness, measured noninvasively by the help of echocardiography, were significantly decreased in the patient group compared to controls (8.0%±1.5% vs. 13.1%±3.3 %; p<0.001 and 3.6±1.1 cm(2).dyn(-1).10(-3) vs. 6.0±2.1 cm(2).dyn(-1).10(-3); p<0.001, respectively). There were negative correlations between NLR and distensibility (r: -0.40; p<0.001) and strain (r: -0.57; p<0.001) in patients with type 1 diabetes.
We have demonstrated that there is a significant negative correlation between the NLR and markers of aortic stiffness in patients with type 1 diabetes, indicating a potential association between inflammation and arterial stiffness. Accordingly, a higher NLR may be a useful additional measure in determining the cardiovascular risks of patients with type 1 diabetes in our clinical practice.
新出现的证据表明，中性粒细胞与淋巴细胞比值（NLR）可能是炎症和主动脉僵硬的有用标志物。炎症和主动脉僵硬的标志物都是心血管事件的指标。因此，我们研究了 NLR 是否与 1 型糖尿病患者的主动脉僵硬有关。
我们检查了 76 例 1 型糖尿病患者和 36 例健康对照者的 NLR 与主动脉僵硬的关系。
1 型糖尿病组的 NLR 高于对照组（分别为 2.33±0.95 和 1.80±0.68；p=0.003）。通过超声心动图无创测量的主动脉应变和主动脉可扩张性，即主动脉僵硬的参数，在患者组中明显低于对照组（分别为 8.0%±1.5%和 13.1%±3.3%；p<0.001 和 3.6±1.1 cm(2).dyn(-1).10(-3)和 6.0±2.1 cm(2).dyn(-1).10(-3)；p<0.001）。1 型糖尿病患者的 NLR 与可扩张性（r：-0.40；p<0.001）和应变（r：-0.57；p<0.001）呈负相关。
我们已经证明，1 型糖尿病患者的 NLR 与主动脉僵硬标志物之间存在显著的负相关，表明炎症和动脉僵硬之间存在潜在的关联。因此，在我们的临床实践中，较高的 NLR 可能是评估 1 型糖尿病患者心血管风险的一个有用的附加指标。
